Recent advances in the use of legume lectins for the diagnosis and treatment of breast cancer

被引：8

作者：

Cavada, Benildo Sousa ^{[1
]}

Oliveira, Messias Vital ^{[1
]}

Osterne, Vinicius Jose Silva ^{[1
,2
]}

Pinto-Junior, Vanir Reis ^{[1
,3
]}

Martins, Francisco William Viana ^{[1
]}

Correia-Neto, Cornevile ^{[1
]}

Pinheiro, Ronald Feitosa ^{[4
]}

Leal, Rodrigo Bainy ^{[5
]}

Nascimento, Kyria Santiago ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Bioquim & Biol Mol, BioMol Lab, Fortaleza, Brazil

[2] Univ Ghent, Dept Biotechnol, Lab Biochem & Glycobiol, Ghent, Belgium

[3] Univ Fed Ceara, Dept Fis, Fortaleza, Brazil

[4] Univ Fed Ceara, Nucleo Pesquisa & Desenvolvimento Medicaco NPDM, Fortaleza, Brazil

[5] Univ Fed Santa Catarina, Dept Bioquim, Florianopolis, SC, Brazil

来源：

BIOCHIMIE | 2023年 / 208卷

关键词：

Plant lectins; Breast cancer; Glycans; MATRIX METALLOPROTEINASE-2 ACTIVATION; ABRUS-PRECATORIUS AGGLUTININ; MANNOSE-BINDING LECTIN; CONCANAVALIN-A; AFFINITY-CHROMATOGRAPHY; POLYGONATUM-CYRTONEMA; CARBOHYDRATE-BINDING; LINKED GLYCOSYLATION; OPHIOPOGON-JAPONICUS; WISTERIA-FLORIBUNDA;

D O I：

10.1016/j.biochi.2022.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poor lifestyle choices and genetic predisposition are factors that increase the number of cancer cases, one example being breast cancer, the third most diagnosed type of malignancy. Currently, there is a demand for the development of new strategies to ensure early detection and treatment options that could contribute to the complete remission of breast tumors, which could lead to increased overall survival rates. In this context, the glycans observed at the surface of cancer cells are presented as efficient tumor cell markers. These carbohydrate structures can be recognized by lectins which can act as decoders of the glycocode. The application of plant lectins as tools for diagnosis/treatment of breast cancer encompasses the detection and sorting of glycans found in healthy and malignant cells. Here, we present an overview of the most recent studies in this field, demonstrating the potential of lectins as: mapping agents to detect differentially expressed glycans in breast cancer, as histochemistry/cytochemistry analysis agents, in lectin arrays, immobilized in chromatographic matrices, in drug delivery, and as biosensing agents. In addition, we describe lectins that present antiproliferative effects by themselves and/or in conjunction with other drugs in a synergistic effect.& COPY; 2022 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：100 / 116

页数：17

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