Heterogeneity of Alzheimer's disease identified by neuropsychological test profiling

被引：2

作者：

Nguyen, Truc Tran Thanh ^{[1
,2
,13
,14
]}

Lee, Hsun-Hua ^{[3
,4
,5
,6
]}

Huang, Li-Kai ^{[4
,7
]}

Hu, Chaur-Jong ^{[4
,7
,8
,9
]}

Yeh, Chih-Yang ^{[10
]}

Yang, Wei-Chung Vivian ^{[11
]}

Lin, Ming-Chin ^{[1
,10
,12
]}

机构：

[1] Taipei Med Univ, Grad Inst Biomed Informat, Div Translat Med, Coll Med Sci & Technol, Taipei, Taiwan

[2] Hosp 30 4, Memory & Dementia Ctr, Ho Chi Minh City, Vietnam

[3] Taipei Med Univ, Taipei Med Univ Hosp, Dept Neurol, Taipei, Taiwan

[4] Taipei Med Univ, Sch Med, Dept Neurol, Coll Med, Taipei, Taiwan

[5] Taipei Med Univ, Shuang Ho Hosp, Dizziness & Balance Disorder Ctr, New Taipei, Taiwan

[6] Taipei Med Univ, Shuang Ho Hosp, Dept Neurol, New Taipei, Taiwan

[7] Taipei Med Univ, Shuang Ho Hosp, Dementia Ctr, Dept Neurol, New Taipei, Taiwan

[8] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Neural Regenerat Med, Taipei, Taiwan

[9] Taipei Med Univ, Taipei Neurosci Inst, Taipei, Taiwan

[10] Taipei Med Univ, Grad Inst Biomed Informat, Div Biomed Informat, Coll Med Sci & Technol, Taipei, Taiwan

[11] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan

[12] Taipei Med Univ, Shuang Ho Hosp, Dept Neurosurg, New Taipei, Taiwan

[13] Natl Taiwan Univ, Taiwan Int Grad Program Interdisciplinary Neurosc, Taipei, Taiwan

[14] Acad Sinica, Taipei, Taiwan

来源：

PLOS ONE | 2023年 / 18卷 / 10期

关键词：

NATIONAL INSTITUTE; DEMENTIA; SUBGROUPS; DIAGNOSIS; SUBTYPES; ATROPHY; SYSTEM;

D O I：

10.1371/journal.pone.0292527

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's disease (AD) is a highly heterogeneous disorder. Untangling this variability could lead to personalized treatments and improve participant recruitment for clinical trials. We investigated the cognitive subgroups by using a data-driven clustering technique in an AD cohort. People with mild-moderate probable AD from Taiwan was included. Neuropsychological test results from the Cognitive Abilities Screening Instrument were clustered using nonnegative matrix factorization. We identified two clusters in 112 patients with predominant deficits in memory (62.5%) and non-memory (37.5%) cognitive domains, respectively. The memory group performed worse in short-term memory and orientation and better in attention than the non-memory group. At baseline, patients in the memory group had worse global cognitive status and dementia severity. Linear mixed effect model did not reveal difference in disease trajectory within 3 years of follow-up between the two clusters. Our results provide insights into the cognitive heterogeneity in probable AD in an Asian population.

引用

页数：16

共 56 条

[1]

Alzheimer's Disease International, 2020, Numbers of people with dementia worldwide: An update to the estimates in the World Alzheimer Report 2015

[2]

American Psychiatric Association, 2022, Diagnostic and Statistical Manual of Mental Disorders Text Revision, V5th ed., text rev.

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