The gut-joint axis mediates the TNF-induced RA process and PBMT therapeutic effects through the metabolites of gut microbiota

被引：4

作者：

Meng, Qingtai ^{[1
]}

Lin, Monan ^{[1
]}

Song, Wuqi ^{[1
,2
]}

Wu, Jiahui ^{[1
]}

Cao, Guoding ^{[1
]}

Huang, Ping ^{[1
]}

Su, Zaiyu ^{[1
]}

Gu, Wei ^{[1
]}

Deng, Xueqing ^{[1
]}

Xu, Peng ^{[1
]}

Yang, Yi ^{[2
]}

Li, Hui ^{[2
]}

Liu, Hailiang ^{[1
,3
]}

Zhang, Fengmin ^{[1
,2
]}

机构：

[1] Harbin Med Univ, WU Lien Teh Inst, Dept Microbiol, Harbin, Peoples R China

[2] Harbin Med Univ, Heilongjiang Prov Key Lab Infect & Immun, Harbin, Peoples R China

[3] Harbin Med Univ, WU Lien Teh Inst, Dept Microbiol, Harbin 150081, Peoples R China

来源：

GUT MICROBES | 2023年 / 15卷 / 02期

关键词：

PBMT; gut microbiota; TNF-Tg mice; rheumatoid arthritis; gut-joint axis; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; FECAL MICROBIOTA; AMINO-ACIDS; METABOLOMICS; EXPRESSION; MODEL;

D O I：

10.1080/19490976.2023.2281382

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut-joint axis, one of the mechanisms that mediates the onset and progression of joint and related diseases through gut microbiota, and shows the potential as therapeutic target. A variety of drugs exert therapeutic effects on rheumatoid arthritis (RA) through the gut-joint axis. However, the anti-inflammatory and immunomodulatory effect of novel photobiomodulatory therapy (PBMT) on RA need further validation and the involvement of gut-joint axis in this process remains unknown. The present study demonstrated the beneficial effects of PBMT on RA, where we found the restoration of gut microbiota homeostasis, and the related key pathways and metabolites after PBMT. We also discovered that the therapeutic effects of PBMT on RA mainly through the gut-joint axis, in which the amino acid metabolites (Alanine and N-acetyl aspartate) play the key role and rely on the activity of metabolic enzymes in the target organs. Together, the results prove that the metabolites of amino acid from gut microbiota mediate the regulation effect on the gut-joint axis and the therapeutic effect on rheumatoid arthritis of PBMT.

引用

页数：22

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