Withanolides from Physalin angulata and Their Inhibitory Effects on Nitric Oxide Production

被引：3
|
作者：
Tan, Yu-Hang [1 ]
Cai, Yu-Xing [1 ]
Kong, Min [1 ]
Li, Ya-Lin [1 ]
Yu, Zhan-Peng [1 ]
Kong, Ling-Yi [1 ]
Luo, Jian-Guang [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 04期
关键词：
Physalis angulata; withanolides; angulasteroidins A-F; NO inhibitory activity; CYTOTOXIC WITHANOLIDES; AERIAL PARTS; VAR; VILLOSA; CONSTITUENTS; PLANTS;
D O I：
10.1002/cbdv.202300195
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six new withanolides, angulasteroidins A-F (1-6), along with twelve known analogs (7-18) were isolated from the whole plants of Physalis angulata. Their structures were elucidated by analysis of 1D and 2D NMR, ECD and IR spectra, HR-ESI-MS data, and ECD calculation. Compounds 1 and 6 were rare 1-10 seco withanolides. Compounds 2-4, 7-9, and 15 exhibited significant inhibitory activity on the production of nitric oxide in the LPS-activated RAW 264.7 mouse macrophage cell lines with IC50 values ranging from 0.23 to 9.06 mu M.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Withanolides from Physalis minima and their inhibitory effects on nitric oxide production
    Guan, Yu-Zhou
    Shan, Si-Ming
    Zhang, Wei
    Luo, Jian-Guang
    Kong, Ling-Yi
    STEROIDS, 2014, 82 : 38 - 43
  • [2] Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
    Yang, Bing-You
    Guo, Rui
    Li, Ting
    Liu, Yan
    Wang, Chang-Fu
    Shu, Zun-Peng
    Wang, Zhi-Bin
    Zhang, Jing
    Xia, Yong-Gang
    Jiang, Hai
    Wang, Qiu-Hong
    Kuang, Hai-Xue
    MOLECULES, 2014, 19 (04): : 4548 - 4559
  • [3] Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS
    Dong, Bangjian
    An, Lijun
    Yang, Xueyuan
    Zhang, Xuke
    Zhang, Jie
    Tuerhong, Muhetaer
    Jin, Da-Qing
    Ohizumi, Yasushi
    Lee, Dongho
    Xu, Jing
    Guo, Yuanqiang
    BIOORGANIC CHEMISTRY, 2019, 87 : 585 - 593
  • [4] A Novel Cytotoxic Physalin from Physalis angulata
    Fan, Jia-Jia
    Liu, Xia
    Zheng, Xi-Long
    Zhao, Hai Yu
    Xia, Huan
    Sun, Yi
    NATURAL PRODUCT COMMUNICATIONS, 2017, 12 (10) : 1589 - 1591
  • [5] Cytotoxic withanolides from Physalis angulata
    Gao, Caiyun
    Li, Ruijun
    Zhou, Miaomiao
    Yang, Yanwei
    Kong, Lingyi
    Luo, Jun
    NATURAL PRODUCT RESEARCH, 2018, 32 (06) : 676 - 681
  • [6] Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production
    Tapondjou, LA
    Lontsi, D
    Sondengam, BL
    Shaheen, F
    Choudhary, MI
    Atta-ur-Rahman
    van Heerden, FR
    Park, HJ
    Lee, KT
    JOURNAL OF NATURAL PRODUCTS, 2003, 66 (09): : 1266 - 1269
  • [7] Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production
    Jin, Qinghao
    Lee, Jin Woo
    Kim, Jun Gu
    Lee, Dongho
    Hong, Jin Tae
    Kim, Youngsoo
    Lee, Mi Kyeong
    Hwang, Bang Yeon
    JOURNAL OF NATURAL PRODUCTS, 2019, 82 (11): : 3002 - 3009
  • [8] Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production
    Qin, Zhi-Bin
    Zhang, Jing
    Wu, Xing-De
    He, Juan
    Ding, Lin-Fen
    Peng, Li-Yan
    Li, Xing-Yao
    Li, Yan
    Deng, Liang
    Guo, Ya-Dong
    Zhao, Qin-Shi
    PLANTA MEDICA, 2014, 80 (8-9) : 703 - 709
  • [9] Eudesmanolides from Taraxacum mongolicum and Their Inhibitory Effects on the Production of Nitric Oxide
    Kim, Young-Hee
    Choo, Soo-Jin
    Ryoo, In-Ja
    Ahn, Jong-Seok
    Yoo, Ick-Dong
    ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (01) : 37 - 41
  • [10] Sesquiterpenoids from Ferula fukanensis and their inhibitory effects on nitric oxide production
    Tsunetake Motai
    Susumu Kitanaka
    Journal of Natural Medicines, 2006, 60 : 54 - 57
12345