Principles of regulatory T cell function

被引：198

作者：

Dikiy, Stanislav ^{[1
,2
,3
]}

Rudensky, Alexander Y. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst & Immunol Program, Sloan Kettering Inst, Ludwig Ctr Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[2] Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USA

[3] Scripps Res, Dept Immunol & Microbiol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

IMMUNITY | 2023年 / 56卷 / 02期

关键词：

TRANSCRIPTION FACTOR FOXP3; CHEMOKINE RECEPTORS CCR4; IFN-GAMMA PRODUCTION; IMMUNE HOMEOSTASIS; TREG CELLS; REG CELLS; LETHAL AUTOIMMUNITY; ADIPOSE-TISSUE; IL-2; RECEPTOR; SELF-ANTIGEN;

D O I：

10.1016/j.immuni.2023.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of Treg cells as principal guardians of the immune system can be attributed to their ability to restrain all currently recognized major types of inflam-matory responses through modulating the activity of a wide range of cells of the innate and adaptive immune system. This broad purview over immunity and inflammation is afforded by the multiple modes of action Treg cells exert upon their diverse molecular and cellular targets. Beyond the suppression of autoimmunity for which they were originally recognized, Treg cells have been implicated in tissue maintenance, repair, and regeneration under physiologic and pathologic conditions. Herein, we discuss the current and emerging un-derstanding of Treg cell effector mechanisms in the context of the basic properties of Treg cells that endow them with such functional versatility.

引用

页码：240 / 255

页数：16

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