Phomopamide A, a cyclic pentadepsipeptide with α-glucosidase inhibition activity from the endophytic fungus Diaporthe sp.

被引：2

作者：

Yu, Zhonghua ^{[1
]}

Nong, Xinmiao ^{[1
,2
]}

Wei, Shanshan ^{[1
,2
]}

Wu, Gang ^{[1
]}

Qin, Qiaomei ^{[1
]}

Tan, Haibo ^{[2
,3
]}

机构：

[1] Guangdong Ecoengn Polytech, Guangzhou, Peoples R China

[2] Chinese Acad Sci, Key Lab South China Agr Plant Mol Anal & Genet Imp, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou, Peoples R China

[3] Gannan Normal Univ, Natl Engn Res Ctr Navel Orange, Ganzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

基金：

中国国家自然科学基金;

关键词：

Artemisia argyi; endophytic fungus; phomopamide A; alpha-glucosidase inhibitory activity; cytotoxic activity; METABOLITES; DERIVATIVES;

D O I：

10.1080/14786419.2024.2309657

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An undescribed cytotoxic cyclopeptide named phomopamide A (1) was isolated from Diaporthe sp., which is an endophytic fungus from Artemisia argyi. Phomopamide A (1) featured an pentadepsipeptide skeleton and composed of two Phe, one Val, one Leu, and one 2-hydroxyoctanoic acid units. The structure of this new compound was fully characterised on the basis of extensive spectroscopic analysis. Moreover, phomopamide A was evaluated for in vitro cyctotoxic and alpha-glucosidase inhibitory activity. As a result, phomopaminde A exhibited no cytotoxic activity against four tumour cell lines, while it showed a potent alpha-glucosidase inhibition effect with IC50 value of 62.35 mu M.

引用

页数：6

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