PREPARATION AND CHARACTERIZATION OF PH-RESPONSIVE ZEIN-ZNPC-PDA/HA NANOPARTICLES INTENDED FOR TUMOR THERAPY

被引：0
作者：
Lu, Huixiang [1 ]
Tian, Xueying [1 ]
He, Xianhui [1 ]
Lu, Yujun [1 ]
Peng, Qianrong [2 ]
Yang, Min [1 ]
机构：
[1] Guizhou Univ, Coll Pharm, Guiyang, Peoples R China
[2] China Tobacco Guizhou Ind Co Ltd, Tech Ctr, Guiyang, Peoples R China
来源：
ACTA POLONIAE PHARMACEUTICA | 2023年 / 80卷 / 01期
基金：
中国国家自然科学基金;
关键词：
photodynamic therapy; zinc phthalocyanine; zein; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; RELEASE; PHTHALOCYANINE; PHOTOSENSITIZERS; ENCAPSULATION; MICROSPHERES; DERIVATIVES; FABRICATION; CURCUMIN;
D O I：
10.32383/appdr/163050
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Phototherapeutics has emerged as a non-invasive modality for tumor therapy. This study proposes a novel Zein nanoparticle (ZP) encapsulating Zinc phthalocyanine (ZnPc) that targets tumors through intravenous delivery. The ZPs were prepared by a phase separation process. Modification of ZPs was realized by encapsulating polydopamine (PDA) and hyaluronic acid (HA) to maintain photothermal, pH-responsive, and tumor-targeting properties. The physicochemical properties, in vitro release, and in vitro evaluation of photothermal and photodynamic effects were studied. The biosafety was analyzed through cytotoxicity assay using human lung cancer cell line A549 as a model. The excellent biosafety and significant anti-tumor effect demonstrated that the novel ZPs could be potential candidates for alternative cancer treatment.
引用
收藏
页码：53 / 62
页数：10
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