DNA Damage and Repair in Eye Diseases

被引：6
作者：
Sohn, Joanna [1 ,2 ]
Lee, Sang-Eun [1 ]
Shim, Eun-Yong [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA
[2] Keystone Sch, 119 E Craig Pl, San Antonio, TX 78212 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
基金：
美国国家卫生研究院;
关键词：
DNA damage and repair; diabetic retinopathy; age-related macular degeneration; glaucoma; BASE EXCISION-REPAIR; OPEN-ANGLE GLAUCOMA; DIABETIC-RETINOPATHY; TRABECULAR MESHWORK; METABOLIC MEMORY; OXIDATIVE STRESS; MITOCHONDRIAL; DEGENERATION; CELLS; BREAK;
D O I：
10.3390/ijms24043916
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vision is vital for daily activities, and yet the most common eye diseases-cataracts, DR, ARMD, and glaucoma-lead to blindness in aging eyes. Cataract surgery is one of the most frequently performed surgeries, and the outcome is typically excellent if there is no concomitant pathology present in the visual pathway. In contrast, patients with DR, ARMD and glaucoma often develop significant visual impairment. These often-multifactorial eye problems can have genetic and hereditary components, with recent data supporting the role of DNA damage and repair as significant pathogenic factors. In this article, we discuss the role of DNA damage and the repair deficit in the development of DR, ARMD and glaucoma.
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页数：12
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