Ferroptosis and Triple-Negative Breast Cancer: A Systematic Overview of Prognostic Insights and Therapeutic Potential

被引：2

作者：

Khan, Mohsin ^{[1
]}

Sunkara, Vyshnavidevi ^{[2
]}

Yadav, Mansi ^{[3
]}

Bokhari, Syed Faqeer Hussain ^{[4
]}

Rehman, Abdur ^{[5
]}

Maheen, Azka ^{[6
]}

Shehryar, Abdullah ^{[7
]}

Chilla, Srikar P. ^{[8
,9
]}

Nasir, Maheen ^{[10
]}

Niaz, Humaira ^{[11
]}

Choudhari, Jinal ^{[12
]}

Anika, Nabila N. ^{[13
]}

Amir, Maaz ^{[14
]}

机构：

[1] Musgrove Pk Hosp, Intervent Radiol, Taunton, England

[2] Katuri Med Coll, Internal Med, Guntur, India

[3] Pandit Bhagwat Dayal Sharma Post Grad Inst Med Sci, Internal Med, Rohtak, India

[4] King Edward Med Univ, Surg, Lahore, Pakistan

[5] Mayo Hosp, Surg, Lahore, Pakistan

[6] Gomal Med Coll, Med, Dera Ismail Khan, Pakistan

[7] Allama Iqbal Med Coll, Internal Med, Lahore, Pakistan

[8] Care Hosp, Med, Hyderabad, India

[9] Univ East London, Sch Hlth Sci, London, England

[10] Natl Univ Med Sci, Anesthesiol, Lahore, Pakistan

[11] Peshawar Med Coll, Internal Med, Peshawar, Pakistan

[12] Larkin Community Hosp, Res & Acad Affairs, Miami, FL USA

[13] Holy Family Red Crescent Med Coll & Hosp, Med, Dhaka, Bangladesh

[14] King Edward Med Univ, Internal Med, Lahore, Pakistan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 01期

关键词：

heterogeneity; therapeutic targets; biomarkers; systematic review; triple-negative breast cancer; prognosis; ferroptosis; CELL-DEATH; FORM;

D O I：

10.7759/cureus.51719

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the realm of oncology, the prognosis and treatment of triple-negative breast cancer (TNBC) have long been challenges for researchers and clinicians. Characterized by its aggressive nature and limited therapeutic options, TNBC demands innovative approaches to understanding its underlying mechanisms and improving patient outcomes. One such avenue of exploration that has emerged in recent years is the study of ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation. Ferroptosis has garnered increasing attention due to its potential relevance in the context of TNBC. This systematic review aims to shed light on the intricate interplay between ferroptosis and the prognosis of TNBC. The article delves into a comprehensive examination of the existing literature to provide a holistic understanding of the subject. By investigating ferroptosis as both an intervention and a prognostic factor in TNBC, this article seeks to unravel its potential as a therapeutic target and prognostic marker. The emerging evidence and heterogeneity of ferroptosis in TNBC underscore the need for a systematic approach to assess its impact on patient outcomes. This review will serve as a valuable resource for researchers, clinicians, and healthcare professionals striving to enhance our knowledge of TNBC and explore novel avenues for prognosis and treatment.

引用

页数：8

共 24 条

[1]

Aysola K., 2013, Hered. Genet, V2013, DOI 10.4172/2161-1041.S2-001

[2] Cysteine depletion induces pancreatic tumor ferroptosis in mice [J].

Badgley, Michael A. ;

Kremer, Daniel M. ;

Maurer, H. Carlo ;

DelGiorno, Kathleen E. ;

Lee, Ho-Joon ;

Purohit, Vinee ;

Sagalovskiy, Irina R. ;

Ma, Alice ;

Kapilian, Jonathan ;

Firl, Christina E. M. ;

Decker, Amanda R. ;

Sastra, Steve A. ;

Palermo, Carmine F. ;

Andrade, Leonardo R. ;

Sajjakulnukit, Peter ;

Zhang, Li ;

Tolstyka, Zachary P. ;

Hirschhorn, Tal ;

Lamb, Candice ;

Liu, Tong ;

Gu, Wei ;

Seeley, E. Scott ;

Stone, Everett ;

Georgiou, George ;

Manor, Uri ;

Iuga, Alina ;

Wahl, Geoffrey M. ;

Stockwell, Brent R. ;

Lyssiotis, Costas A. ;

Olive, Kenneth P. .

SCIENCE, 2020, 368 (6486) :85-+

[3] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J].

Bersuker, Kirill ;

Hendricks, Joseph M. ;

Li, Zhipeng ;

Magtanong, Leslie ;

Ford, Breanna ;

Tang, Peter H. ;

Roberts, Melissa A. ;

Tong, Bingqi ;

Maimone, Thomas J. ;

Zoncu, Roberto ;

Bassik, Michael C. ;

Nomura, Daniel K. ;

Dixon, Scott J. ;

Olzmann, James A. .

NATURE, 2019, 575 (7784) :688-+

[4] Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells [J].

Consoli, Valeria ;

Sorrenti, Valeria ;

Pittala, Valeria ;

Greish, Khaled ;

D'Amico, Agata Grazia ;

Romeo, Giuseppe ;

Intagliata, Sebastiano ;

Salerno, Loredana ;

Vanella, Luca .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (10)

[5] Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells [J].

Ding, Yahui ;

Chen, Xiaoping ;

Liu, Can ;

Ge, Weizhi ;

Wang, Qin ;

Hao, Xin ;

Wang, Mengmeng ;

Chen, Yue ;

Zhang, Quan .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)

[6] Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death [J].

Dixon, Scott J. ;

Lemberg, Kathryn M. ;

Lamprecht, Michael R. ;

Skouta, Rachid ;

Zaitsev, Eleina M. ;

Gleason, Caroline E. ;

Patel, Darpan N. ;

Bauer, Andras J. ;

Cantley, Alexandra M. ;

Yang, Wan Seok ;

Morrison, Barclay, III ;

Stockwell, Brent R. .

CELL, 2012, 149 (05) :1060-1072

[7]

Doll S, 2017, NAT CHEM BIOL, V13, P91, DOI [10.1038/NCHEMBIO.2239, 10.1038/nchembio.2239]

[8] Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition [J].

Hangauer, Matthew J. ;

Viswanathan, Vasanthi S. ;

Ryan, Matthew J. ;

Bole, Dhruv ;

Eaton, John K. ;

Matov, Alexandre ;

Galeas, Jacqueline ;

Dhruv, Harshil D. ;

Berens, Michael E. ;

Schreiber, Stuart L. ;

McCormick, Frank ;

McManus, Michael T. .

NATURE, 2017, 551 (7679) :247-+

[9] Targeting Ferroptosis to Iron Out Cancer [J].

Hassannia, Behrouz ;

Vandenabeele, Peter ;

Vanden Berghe, Tom .

CANCER CELL, 2019, 35 (06) :830-849

[10] Ferroptosis: mechanisms, biology and role in disease [J].

Jiang, Xuejun ;

Stockwell, Brent R. ;

Conrad, Marcus .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021, 22 (04) :266-282

← 1 2 3 →