Omnipresence MicroRNA-483: A comprehensive organ by organ literature review

被引:1
作者
Asadi, Mehrdad [1 ]
Zolfi-Gol, Ali [2 ]
Mosarrezaii, Arash [3 ]
Mehran, Shiva [4 ]
Gholinejad, Zafar [5 ]
机构
[1] Islamic Azad Univ, Fac Med Sci, Dept Med Lab Sci & Microbiol, Tabriz Med Sci, Tabriz, Iran
[2] Urmia Univ Med Sci, Shahid Motahari Hosp, Dept Pediat Cardiol, Orumiyeh, Iran
[3] Urmia Univ Med Sci, Dept Neurol, Orumiyeh, Iran
[4] Higher Educ Inst Rabe Rashidi, Dept Biol, Tabriz, Iran
[5] Islamic Azad Univ, Dept Med Lab Sci, Urmia Branch, Orumiyeh, Iran
来源
HUMAN GENE | 2023年 / 37卷
关键词
MiR-483; Cancer; Cardiovascular; Neurologic disorders; Biomarker; SQUAMOUS-CELL CARCINOMA; CIRCULATING MICRORNAS; SERUM MICRORNAS; ALCOHOLIC HEPATITIS; MESENCHYMAL TRANSITION; DIAGNOSTIC BIOMARKERS; EXPRESSION PROFILES; SEQUENCING REVEALS; PLASMA MICRORNA; MIR-483-5P;
D O I
10.1016/j.humgen.2023.201195
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
MiR-483, insulin-like growth factor 2 gene-derived microRNAs (miRNA), play an important role in the pathogenesis of several diseases in different organs. Serum and tissue levels of miR-483 were proposed as a biomarker for differential diagnosis, prognosis, disease outcome and survival prediction biomarker. Some studies tried to discriminate the function of miR-483 from the function of its host gene, insulin growth factor-2 (IGF-2), and discussed the complex regulation of this transcriptional product. MiR-483 targets the genes in a tissue and organspecific manner. According to the target cell type, miR-483 can induce cell proliferation, cell death, apoptosis, and cell differentiation. In several pathologic conditions, miR-483 levels are up- or down-regulated including cancers, cardiovascular diseases, and neurologic disorders, gynecological disorders and gastrointestinal system. Metabolic disorders and bone metabolism are the other conditions in which miR-483 is involved. In this review, we discuss the miR-483 structure and its clinical importance in the diseases organ by organ.
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页数:14
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