Associations of Nut Consumption with All-Cause Mortality among Individuals with Type 2 Diabetes

被引:2
作者
Zhang, Xuena [1 ,2 ,3 ]
Ou, Yunjing [1 ,2 ]
Li, Lin [1 ,2 ]
Wan, Zhenzhen [1 ,2 ]
Lu, Qi [1 ,2 ]
Geng, Tingting [4 ]
Liu, Yujie [1 ,2 ]
Qiu, Zixin [1 ,2 ]
Zhu, Kai [1 ,2 ]
Yang, Kun [5 ]
Pan, An [6 ]
Liu, Gang [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Minist Educ,Hubei Key Lab Foo, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan, Peoples R China
[3] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Dept Hosp Infect Management, Wuhan, Peoples R China
[4] Fudan Univ, Inst Nutr, Sch Publ Hlth, Dept Nutr & Food Hyg, Shanghai, Peoples R China
[5] Hubei Univ Med, Affiliated Dongfeng Hosp, Dept Endocrinol, Shiyan, Peoples R China
[6] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
nuts; mortality; diabetes; epidemiology; CARDIOVASCULAR-DISEASE; GLYCEMIC CONTROL; RISK; CANCER; EPIDEMIOLOGY; MELLITUS; GLUCOSE; HEALTH; PEANUT; WOMEN;
D O I
10.1016/j.tjnut.2023.08.004
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Nuts are energy-dense, high-fat foods, and whether nut consumption influences mortality risk among individuals with type 2 diabetes (T2D) remains unclear.Objectives: This study aimed to investigate the associations of nut consumption with all-cause mortality among adults with T2D and to further explore the potential mediation effects of cardiometabolic biomarkers.Methods: The current analysis included 5090 US participants with T2D from the National Health and Nutrition Examination Survey (1999-2014). Cox proportional hazards models were conducted to estimate hazard ratio (HR) and 95% confidence interval (CI).Results: After 35,632 person-y of follow-up, 1174 deaths were documented. Higher nut consumption was significantly associated with a lower risk of all-cause mortality among individuals with T2D. After multivariable adjustment including lifestyles and dietary factors, diabetes duration, and glycated hemoglobin, compared with participants who did not consume nuts, the HR (95% CI) for those who consumed nuts over 3.5 ounce equivalent (oz.eq)/wk was 0.64 (0.50, 0.82; P -trend < 0.001) for all-cause mortality. A linear dose-response relationship was observed between nut consumption and all-cause mortality among individuals with T2D (Poverall=0.004, Pnonlinearity=0.35). In substitution analyses, replacing one serving of red and processed meat, refined grains, eggs, and dairy foods with one serving of nuts was associated with a 18% to 22% lower risk of all-cause mortality. In addition, mediation analysis suggested that C-reactive protein and gamma-glutamine transaminase explained 6.7% and 9.1% of the relationship between nut consumption with all-cause mortality, respectively.Conclusions: Higher nut consumption was significantly associated with lower all-cause mortality among individuals with T2D. These findings indicate a potential benefit of nut consumption in the prevention of premature death among individuals with T2D.
引用
收藏
页码:3003 / 3011
页数:9
相关论文
共 51 条
[1]   Nut and Peanut Butter Consumption and Mortality in the National Institutes of Health-AARP Diet and Health Study [J].
Amba, Vineeth ;
Murphy, Gwen ;
Etemadi, Arash ;
Wang, ShaoMing ;
Abnet, Christian C. ;
Hashemian, Maryam .
NUTRIENTS, 2019, 11 (07)
[2]  
[Anonymous], Food Patterns Equivalents Database (FPED) | National Agricultural Library
[3]  
[Anonymous], SAS code to run mediate macro (SAS version 9 or above)
[4]  
[Anonymous], 2021, IDF Diabetes Atlas, V10th
[5]  
[Anonymous], Healthy eating index SAS code
[6]  
[Anonymous], Codebook for the 2015 public-use linked mortality file (LMF)
[7]   Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies [J].
Aune, Dagfinn ;
Keum, NaNa ;
Giovannucci, Edward ;
Fadnes, Lars T. ;
Boffetta, Paolo ;
Greenwood, Darren C. ;
Tonstad, Serena ;
Vatten, Lars J. ;
Riboli, Elio ;
Norat, Teresa .
BMC MEDICINE, 2016, 14
[8]   Association of Nut Consumption with Total and Cause-Specific Mortality [J].
Bao, Ying ;
Han, Jiali ;
Hu, Frank B. ;
Giovannucci, Edward L. ;
Stampfer, Meir J. ;
Willett, Walter C. ;
Fuchs, Charles S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (21) :2001-2011
[9]   Physical Activity and Mortality in Chronic Kidney Disease (NHANES III) [J].
Beddhu, Srinivasan ;
Baird, Bradley C. ;
Zitterkoph, Jennifer ;
Neilson, Jill ;
Greene, Tom .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (12) :1901-1906
[10]   Dietary Protein Sources and the Risk of Stroke in Men and Women [J].
Bernstein, Adam M. ;
Pan, An ;
Rexrode, Kathryn M. ;
Stampfer, Meir ;
Hu, Frank B. ;
Mozaffarian, Dariush ;
Willett, Walter C. .
STROKE, 2012, 43 (03) :637-+