Role of haemostatic disorders in abnormal uterine bleeding

Abnormal uterine bleeding is a haemorrhagic manifestation that affects women's quality of life by limiting their work and social activities. It is often the first manifestation of an underlying bleeding disorder, so its early identification is essential to avoid delays in treatment.Congenital bleeding disorders include a wide variety of haemostatic defects. Among them, von Willebrand disease is the most prevalent. Less frequently we find congenital platelet disor-ders and deficiencies of other coagulation factors that can also manifest with abnormal uterine bleeding. There is wide variation in the severity of bleeding manifestations among different disorders of haemostasis, as well as among different patients with the same disorder. These manifestations can be mild, moderate, or present severe bleeding diathesis. Therefore, each patient must be assessed individually. The management of women with abnormal uterine blee-ding and haemostasis disorders is multidisciplinary with the joint participation of gynaecologists and haematologists.For the diagnosis of a bleeding disorder associated with abnormal uterine bleeding, clinical suspicion is essential, as well as taking a targeted personal and family history, using standardized tools that assess the magnitude of the bleeding, and performing a series of laboratory studies to confirm the diagnosis. Treatment will be individualized based on the severity of the clinical manifestations and the type of underlying haemostasis alteration. & COPY; 2022 Elsevier Espana, S.L.U. All rights reserved.