Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth

被引：10

作者：

Olga, Laurentya ^{[1
]}

van Diepen, Janna A. ^{[2
]}

Chichlowski, Maciej ^{[2
]}

Petry, Clive J. ^{[1
]}

Vervoort, Jacques ^{[3
]}

Dunger, David B. ^{[1
,4
]}

Kortman, Guus A. M. ^{[5
]}

Gross, Gabriele ^{[2
]}

Ong, Ken K. ^{[1
,4
,6
]}

机构：

[1] Univ Cambridge, Dept Paediat, Cambridge CB2 0QQ, England

[2] Reckitt Mead Johnson Nutr Inst, Med & Sci Affairs, Evansville, IN 47721 USA

[3] Wageningen Univ, Dept Agrotechnol & Food Sci, NL-6708 WE Wageningen, Netherlands

[4] Univ Cambridge, MRC Inst Metab Sci, NIHR Cambridge Comprehens Biomed Res Ctr, MRC Epidemiol Unit, Cambridge CB2 0SL, England

[5] NIZO Food Res BV, NL-6718 ZB Ede, Netherlands

[6] Univ Cambridge, Inst Metab Sci, Cambridge CB2 0QQ, England

来源：

NUTRIENTS | 2023年 / 15卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

human milk butyrate; human milk microbiota; human milk intake volume; butyrate intake; infant growth; infant adiposity; infant weight gain; BREAST-MILK; BACTERIA; DIET; SENSITIVITY; METABOLISM; GREENGENES; INTERPLAY; APPETITE; DATABASE; WEIGHT;

D O I：

10.3390/nu15040916

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate's origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby Growth and Breastfeeding Study (CBGS-BF), in which infants (n = 59) were exclusively breastfed for at least 6 weeks. Infant growth (birth, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months) and HM butyrate concentrations (2 weeks, 6 weeks, 3 months, and 6 months) were measured. At age 6 weeks, HM intake volume was measured by deuterium-labelled water technique and HM microbiota by 16S sequencing. Cross-sectionally at 6 weeks, HM butyrate was associated with HM microbiota composition (p = 0.036) although no association with the abundance of typical butyrate producers was detected. In longitudinal analyses across all time points, HM butyrate concentrations were overall negatively associated with infant weight and adiposity, and associations were stronger at younger infant ages. HM butyrate concentration was also inversely correlated with HM intake volume, supporting a possible mechanism whereby butyrate might reduce infant growth via appetite regulation and modulation of HM intake.

引用

页数：14

共 52 条

[1] Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice [J].