Clinical features and allograft failure rates of pulmonary antibody-mediated rejection categories

被引：8

作者：

Charya, Ananth, V ^{[1
,2
,3
]}

Ponor, Ileana L. ^{[1
,3
,4
]}

Cochrane, Adam ^{[5
]}

Levine, Deborah ^{[6
]}

Philogene, Mary ^{[7
]}

Fu, Yi-Ping ^{[8
]}

Jang, Moon K. ^{[1
,3
]}

Kong, Hyesik ^{[1
,3
]}

Shah, Pali ^{[9
]}

Bon, Ann Mary ^{[1
,3
]}

Krishnan, Aravind ^{[10
]}

Mathew, Joby ^{[9
]}

Luikart, Helen ^{[11
]}

Khush, Kiran K. ^{[11
]}

Berry, Gerald ^{[1
,12
]}

Marboe, Charles ^{[1
,13
]}

Iacono, Aldo ^{[1
,2
]}

Orens, Jonathan B. ^{[1
,9
]}

Nathan, Steven D. ^{[1
,5
,14
]}

Agbor-Enoh, Sean ^{[1
,3
,9
,15
]}

机构：

[1] Genom Res Alliance Transplantat GRAfT, Bethesda, MD USA

[2] Univ Maryland, Div Pulm & Crit Care, Med Ctr, Baltimore, MD USA

[3] NHLBI, Lab Appl Precis Om, Div Intramural Res, Bethesda, MD 20892 USA

[4] Johns Hopkins Bayview Med Ctr, Div Hosp Med, Baltimore, MD USA

[5] Inova Fairfax Hosp, Adv Lung Dis & Lung Transplantat Program, Fairfax, VA USA

[6] Univ Texas San Antonio, Lung Transplantat Program, San Antonio, TX USA

[7] Histocompatibil & Mol Genet Lab, Philadelphia, PA USA

[8] NHLBI, Biostat, Div Intramural Res, NIH, Bethesda, MD 20892 USA

[9] Johns Hopkins Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA

[10] Stanford Univ, Dept Cardiothorac Surg, Sch Med, Stanford, CA USA

[11] Stanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA USA

[12] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA USA

[13] New York Presbyterian Univ Hosp Cornell & Columbia, Dept Pathol, New York, NY USA

[14] Inova Fairfax Hosp, Adv Lung Dis & Lung Transplantat Program, 3300 Gallows Rd, Falls Church, VA 22042 USA

[15] NHLBI, Lab Appl Precis Om, Genom Res Alliance Transplantat GRAfT, Div Intramural Res, 10 Ctr Dr,Rm 7D05, Bethesda, MD 20892 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2023年 / 42卷 / 02期

基金：

美国国家卫生研究院;

关键词：

antibody-mediated rejection; chronic lung allograft dysfunction; death; clinical features; CELL-FREE DNA; BRONCHIOLITIS OBLITERANS SYNDROME; LUNG;

D O I：

10.1016/j.healun.2022.09.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Pulmonary antibody-mediated rejection (AMR) consensus criteria categorize AMR by diagnostic certainty. This study aims to define the clinical features and associated outcomes of these recently defined AMR categories.METHODS: Adjudication committees reviewed clinical data of 335 lung transplant recipients to define clinical or subclinical AMR based on the presence of allograft dysfunction, and the primary endpoints, time from transplant to allograft failure, a composite endpoint of chronic lung allograft dysfunction and/or death. Clinical AMR was subcategorized based on diagnostic certainty as definite, probable or possible AMR if 4, 3, or 2 characteristic features were present, respectively. Allograft injury was assessed via plasma donor-derived cell-free DNA (ddcfDNA). Risk of allograft failure and allograft injury was compared for AMR categories using regression models.RESULTS: Over the 38.5 months follow-up, 28.7% of subjects developed clinical AMR (n = 96), 18.5% developed subclinical AMR (n = 62) or 58.3% were no AMR (n = 177). Clinical AMR showed higher risk of allograft failure and ddcfDNA levels compared to subclinical or no AMR. Clinical AMR included definite/probable (n = 21) or possible AMR (n = 75). These subcategories showed similar clin-ical characteristics, ddcfDNA levels, and risk of allograft failure. However, definite/probable AMR showed greater measures of AMR severity, including degree of allograft dysfunction and risk of death compared to possible AMR. CONCLUSIONS: Clinical AMR showed greater risk of allograft failure than subclinical AMR or no AMR. Subcategorization of clinical AMR based on diagnostic certainty correlated with AMR severity and risk of death, but not with the risk of allograft failure. J Heart Lung Transplant 2023;42:226-235 (c) 2022 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：226 / 235

页数：10

共 28 条

[1] Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation [J].

Agbor-Enoh, Sean ;

Wang, Yan ;

Tunc, Ilker ;

Jang, Moon Kyoo ;

Davis, Andrew ;

De Vlaminck, Iwijn ;

Luikart, Helen ;

Shah, Pali D. ;

Timofte, Irina ;

Brown, Anne W. ;

Marishta, Argit ;

Bhatti, Kenneth ;

Gorham, Sasha ;

Fideli, Ulgen ;

Wylie, Jennifer ;

Grimm, David ;

Goodwin, Natalie ;

Yang, Yanqin ;

Patel, Kapil ;

Zhu, Jun ;

Laconoad, Aldo ;

Orens, Jonathan B. ;

Nathan, Steven D. ;

Marboe, Charles ;

Berry, Gerald J. ;

Quake, Stephen R. ;

Khush, Kiran ;

Valantine, Hannah A. .

EBIOMEDICINE, 2019, 40 :541-553

[2] Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: Evidence from cell-free DNA analysis [J].

Agbor-Enoh, Sean ;

Jackson, Annette M. ;

Tunc, Ilker ;

Berry, Gerald J. ;

Cochrane, Adam ;

Grimm, David ;

Davis, Andrew ;

Shah, Pali ;

Brown, Anne W. ;

Wang, Yan ;

Timofte, Irina ;

Shah, Palak ;

Gorham, Sasha ;

Wylie, Jennifer ;

Goodwin, Natalie ;

Jang, Moon Kyoo ;

Marishta, Argit ;

Bhatti, Kenneth ;

Fideli, Ulgen ;

Yang, Yanqin ;

Luikart, Helen ;

Cao, Zeling ;

Pirooznia, Mehdi ;

Zhu, Jun ;

Marboe, Charles ;

Iacono, Aldo ;

Nathan, Steven D. ;

Orens, Jonathan ;

Valantine, Hannah A. ;

Khush, Kiran .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2018, 37 (07) :925-932

[3] The role of C4d deposition in the diagnosis of antibody-mediated rejection after lung transplantation [J].

Aguilar, P. R. ;

Carpenter, D. ;

Ritter, J. ;

Yusen, R. D. ;

Witt, C. A. ;

Byers, D. E. ;

Mohanakumar, T. ;

Kreisel, D. ;

Trulock, E. P. ;

Hachem, R. R. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 (04) :936-944

[4] Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT [J].

Berry, Gerald ;

Burke, Margaret ;

Andersen, Claus ;

Angelini, Annalisa ;

Bruneval, Patrick ;

Calbrese, Fiorella ;

Fishbein, Michael C. ;

Goddard, Martin ;

Leone, Ornella ;

Maleszewski, Joseph ;

Marboe, Charles ;

Miller, Dylan ;

Neil, Desley ;

Padera, Robert ;

Rassi, Doris ;

Revell, Monica ;

Rice, Alexandra ;

Stewart, Susan ;

Yousem, Samuel A. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2013, 32 (01) :14-21

[5] Role of C1q-binding anti-HLA antibodies as a predictor of Lung allograft outcome [J].

Brugiere, Olivier ;

Roux, Antoine ;

Le Pavec, Jerome ;

Sroussi, Deborah ;

Parquin, Francois ;

Pradere, Pauline ;

Dupin, Clairelyne ;

Bunel, Vincent ;

Mourin, Gisele ;

Jebrak, Gilles ;

Dauriat, Gaelle ;

Castier, Yves ;

Mordant, Pierre ;

Lortat-Jacob, Brice ;

Jean-Baptiste, Sylvain ;

Mal, Herve ;

Suberbielle, Caroline ;

Gautreau, Chantal ;

Caillat-Zucman, Sophie ;

Cazes, Aurelie ;

Thabut, Gabriel ;

Taupin, Jean-Luc .

EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (02)

[6] Noninvasive monitoring of infection and rejection after lung transplantation [J].

De Vlaminck, Iwijn ;

Martin, Lance ;

Kertesz, Michael ;

Patel, Kapil ;

Kowarsky, Mark ;

Strehl, Calvin ;

Cohen, Garrett ;

Luikart, Helen ;

Neff, Norma F. ;

Okamoto, Jennifer ;

Nicolls, Mark R. ;

Cornfield, David ;

Weill, David ;

Valantine, Hannah ;

Khush, Kiran K. ;

Quake, Stephen R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (43) :13336-13341

[7] Pathologic findings in lung allografts with anti-HLA antibodies [J].

DeNicola, Matthew M. ;

Weigt, Sam S. ;

Belperio, John A. ;

Reed, Elaine F. ;

Ross, David J. ;

Wallace, W. Dean .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2013, 32 (03) :326-332

[8] Proteasome Inhibitor Carfilzomib-Based Therapy for Antibody-Mediated Rejection of the Pulmonary Allograft: Use and Short-Term Findings [J].

Ensor, C. R. ;

Yousem, S. A. ;

Marrari, M. ;

Morrell, M. R. ;

Mangiola, M. ;

Pilewski, J. M. ;

D'Cunha, J. ;

Wisniewski, S. R. ;

Venkataramanan, R. ;

Zeevi, A. ;

McDyer, J. F. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 (05) :1380-1388

[9] Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation [J].

Garcia Moreira, Vanessa ;

Prieto Garcia, Belen ;

Baltar Martin, Jose M. ;

Ortega Suarez, Francisco ;

Alvarez, Francisco V. .

CLINICAL CHEMISTRY, 2009, 55 (11) :1958-1966

[10] The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review [J].

Gogenur, Mikail ;

Burcharth, Jakob ;

Gogenur, Ismail .

CRITICAL CARE, 2017, 21

← 1 2 3 →