Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4

被引：5

作者：

Liu, Xue ^{[1
,2
,3
]}

Liang, Huichun ^{[3
]}

Fang, Huan ^{[3
]}

Xiao, Ji ^{[4
]}

Yang, Chuanyu ^{[3
]}

Zhou, Zhongmei ^{[5
]}

Feng, Jing ^{[2
,8
]}

Chen, Ceshi ^{[3
,6
,7
]}

机构：

[1] Anhui Univ Sci & Technol, Coll Med, Huainan 232001, Peoples R China

[2] Fengxian Dist Cent Hosp Shanghai, Dept Lab Med & Cent Lab, Shanghai 201499, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650201, Yunnan, Peoples R China

[4] Jinan Univ, Guangzhou Jinan Biomed Res & Dev Ctr, Coll Life Sci & Technol, Guangzhou 510632, Peoples R China

[5] Kunming Med Univ, Sch Continuing Educ, Kunming 650500, Yunnan, Peoples R China

[6] Kunming Med Univ, Acad Biomed Engn, Kunming 650500, Yunnan, Peoples R China

[7] Kunming Med Univ, Affiliated Hosp 3, Kunming 650106, Yunnan, Peoples R China

[8] Chinese Univ Hong Kong, Affiliated Hosp 2, Shenzhen 518172, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2023年 / 55卷 / 09期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

angiopoietin-1; carboxypeptidase A4; cell proliferation; cell cycle; triple-negative breast cancer; TUMOR-GROWTH; CPA4; EXPRESSION; BIOMARKER; ANGIOGENESIS; ASSOCIATION; PROGRESSION; INHIBITOR;

D O I：

10.3724/abbs.2023082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.

引用

页码：1487 / 1495

页数：9

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