Antimycic Acid and its Acetyl Derivative from Deep-sea-derived Alcanivorax sp. SHA4 with Neuroprotective Properties

被引：0

作者：

Chen, Shuang ^{[1
]}

Zhang, Da-shan ^{[2
]}

Wang, Jin-hui ^{[1
]}

机构：

[1] Hainan Inst Zhejiang Univ, Sanya, Peoples R China

[2] Ocean Coll Zhejiang Univ, Inst Marine Biol & Pharmacol, Zhoushan, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2023年 / 18卷 / 01期

关键词：

bioactivity; neuroprotective properties; Alcanivorax; deep sea; Marfey's method; METABOLITES;

D O I：

10.1177/1934578X221110661

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of secondary metabolites of the deep-sea-derived Alcanivorax sp. SHA4 identified a new compound 1 which was antimycic acid (2)'s acetyl derivative, and 11 known compounds (2-12). Their structures were elucidated by extensive nuclear magnetic resonance and mass spectrometry spectroscopic analyses, and the absolute configuration of compound 1 was determined by Marfey's method. Bioactivity assays indicated that compounds 1 and 2 exhibited significant neuroprotective properties against glutamate-induced PC12 cell death in 0.02-0.31 mu M.

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页数：5

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