Age-Related Features of the Early Period of Liver Regeneration after Partial Hepatectomy in Rats

被引：2
|
作者：
Pan, E. S. [1 ]
Ermakova, N. N. [1 ]
Pershina, O. V. [1 ]
Pakhomova, A. V. [1 ]
Zhukova, M. A. [1 ]
Sandrikina, L. A. [1 ]
Kogai, L. V. [1 ]
Afanas'ev, S. A. [3 ]
Rebrova, T. Yu. [3 ]
Korepanov, V. A. [3 ]
Morozov, S. G. [2 ]
Kubitaev, A. A. [2 ]
Dygai, A. M. [1 ,2 ]
Skurikhin, E. G. [2 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[3] Russian Acad Sci, Tomsk Natl Res Med Ctr, Cardiol Res Inst, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 176卷 / 02期
关键词：
liver resection; age-related features; stem and progenitor cells; hepatocytes; membrane microviscosity; MICE;
D O I：
10.1007/s10517-024-05985-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Regenerative processes in the liver were studied in 3-month-old (young) and 9-month-old (aged) male Wistar rats on day 1 after 30 and 70% hepatectomy. Regardless of the resected liver volume, shifts in the biochemical parameters of the serum in aged rats were more pronounced than in young animals. After 30% hepatectomy, no age differences in the rate of hepatic regeneration were found, while after 70% liver resection this parameter was higher in young rats. Hepatectomy in young rats led to recruitment of MSC, hepatocyte precursors, endothelial and epithelial progenitor cells into the liver parenchyma and increased fluidity of the plasma and mitochondrial membranes of hepatocytes. In aged rats, the recruitment of MSC, hepatocyte precursors, and endothelial progenitor cells into the injured liver was impaired and the rigidity of the mitochondrial membranes of hepatocytes increased.
引用
收藏
页码：235 / 240
页数：6
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