Vitamin D Intake Attenuated the Association between Pesticides Exposure and Female Infertility

Background: Only a few epidemiological studies have illuminated the association between pesticide exposure and female infertility. However, evidence of the available data is restricted and also controversial. Vitamin D supplement was considered as having a beneficial effect on fertility. So, the purpose of our study is to assess the effect of dietary vitamin D consumption on the relationship between pesticide exposure in home and female infertility. Methods: There were a total of 2,968 subjects from the National Health and Nutrition Examination Survey (NHANES), 2011 -2018. The daily vitamin D intake was divided into two groups high intake (>= 6 mu g/d) and low intake (< 6 mu g/d). Multi-variable logistic regression analysis was used to assess the relationship among vitamin D intake, pesticide exposure, and female infertility.Results: We found a significant association between household pesticide exposure and infertility on a basis of a fully-adjusted model (OR 1.61; 95% CI 1.1 -2.37). Furthermore, the relationship between pesticide exposure and in-fertility differed from low vitamin D intake group (OR 3.96; 95% CI 1.77 -8.86) and high intake group (OR 1.36, 95% CI: 0.86 -2.16), and p for interaction is 0.043 stratified by vitamin D intake.Conclusions: A significant association of female infertility with pesticide exposure in home is modified by dietary vitamin D consumption. This was the first study to demonstrate that dietary vitamin D may alter associations of human female infertility with pesticide exposure in home.