Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy

被引：14

作者：

Al'Aref, Subhi J. ^{[1
]}

Altibi, Ahmed M. ^{[2
]}

Malkawi, Abdallah ^{[1
]}

Mansour, Munthir ^{[1
]}

Baskaran, Lohendran ^{[3
]}

Masri, Ahmad ^{[2
]}

Rahmouni, Hind ^{[2
]}

Abete, Raffaele ^{[4
]}

Andreini, Daniele ^{[5
]}

Aquaro, Giovanni ^{[6
]}

Barison, Andrea ^{[6
]}

Bogaert, Jan ^{[7
]}

Camastra, Giovanni ^{[8
]}

Carigi, Samuela ^{[9
]}

Carrabba, Nazario ^{[10
]}

Casavecchia, Grazia ^{[11
]}

Censi, Stefano ^{[12
]}

Cicala, Gloria ^{[13
]}

Conte, Edoardo ^{[5
]}

De Cecco, Carlo N. ^{[14
]}

De Lazzari, Manuel ^{[15
]}

Di Giovine, Gabriella ^{[4
]}

Di Roma, Mauro ^{[16
]}

Dobrovie, Monica ^{[7
]}

Focardi, Marta ^{[17
]}

Gaibazzi, Nicola ^{[18
]}

Gismondi, Annalaura ^{[17
]}

Gravina, Matteo ^{[19
]}

Guglielmo, Marco ^{[5
]}

Lanzillo, Chiara ^{[20
]}

Lombardi, Massimo ^{[21
]}

Lorenzoni, Valentina ^{[22
]}

Lozano-Torres, Jordi ^{[23
]}

Margonato, Davide ^{[4
]}

Martini, Chiara ^{[24
]}

Marzo, Francesca ^{[9
]}

Masci, Piergiorgio ^{[25
]}

Masi, Ambra ^{[26
]}

Memeo, Riccardo ^{[27
]}

Moro, Claudio ^{[28
]}

Mushtaq, Saima ^{[5
]}

Nese, Alberto ^{[29
]}

Palumbo, Alessandro ^{[30
]}

Pavon, Anne Giulia ^{[31
]}

Pedrotti, Patrizia ^{[26
]}

Pepi, Mauro ^{[5
]}

Perazzolo Marra, Martina ^{[15
]}

Pica, Silvia ^{[21
]}

Pradella, Silvia ^{[32
]}

Presicci, Cristina ^{[24
]}

机构：

[1] Univ Arkansas Med Sci, Dept Med, Div Cardiol, Little Rock, AR 72205 USA

[2] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97201 USA

[3] Natl Heart Ctr, Dept Cardiovasc Med, Singapore, Singapore

[4] Policlin Monza, Dept Cardiol, Monza, Italy

[5] Univ Milan, Ctr Cardiol Monzino IRCCS, Milan, Italy

[6] Fdn G Monasterio CNR Reg Toscana Pisa, UOC Risonanza Magnet Immagini, Pisa, Italy

[7] Univ Hosp Leuven, Dept Radiol, Leuven, Belgium

[8] Vannini Hosp Rome, Cardiac Dept, Rome, Italy

[9] Infermi Hosp, Dept Cardiol, Rimini, Italy

[10] Careggi Hosp, Cardiovasc & Thorac Dept, Florence, Italy

[11] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy

[12] Maria Cecilia Hosp, GVM Care & Res, Cotignola, RA, Italy

[13] Parma Univ Hosp, Radiol Dept, Via Gramsci, Parma, Italy

[14] Emory Univ, Div Cardiothorac Imaging, Atlanta, GA 30322 USA

[15] Univ Padua, Med Sch, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Padua, Italy

[16] Policlin Casilino, Radiol Dept, Rome, Italy

[17] Univ Siena, Dept Med Biotechnol, Div Cardiol, Siena, Italy

[18] Azienda Osped Univ, Dept Cardiol, Parma, Italy

[19] Univ Foggia, Dept Radiol, Foggia, Italy

[20] Policlin Casilino, Cardiol Dept, Rome, Italy

[21] IRCCS Policlin San Donato, Multimodal Cardiac Imaging Sect, Milan, Italy

[22] Scuola Super Sant Anna, Inst Management, Pisa, Italy

[23] Univ Autonoma Barcelona, Vall dHebron Inst Recerca VHIR, Dept Cardiol, Barcelona, Spain

[24] Univ Parma, Dept Med & Surg, Sci Radiol, Parma, Italy

[25] Kings Coll London, Sch Biomed Engn & Imaging Sci, London, England

[26] ASST Grande Osped Metropolitano Niguarda, De Gasperis Cardio Ctr, Milan, Italy

[27] Univ Hosp Policlin Bari, Dept Emergency & Organ Transplantat, Inst Cardiovasc Dis, Bari, Italy

[28] ASST Monza, Dept Cardiol, PO Desio, Desio, Italy

[29] Osped Ca Foncello Treviso, Dipartimento Neurocardiovasc, Treviso, Italy

[30] CHU Vaudois, Univ Hosp Lausanne, CMR Ctr, Cardiovasc Dept, Lausanne, Switzerland

[31] Careggi Hosp, Dept Radiol, Florence, Italy

[32] Loyola Univ Chicago, Div Cardiol, Chicago, IL USA

[33] Citta Salute & Sci Osped Molinette, Dept Cardiol, Turin, Italy

[34] Vannini Hosp Rome, Radiol Dept, Rome, Italy

[35] Med Univ South Carolina, Dept Radiol & Radiol Sci, Div Cardiovasc Imaging, Charleston, SC 29425 USA

[36] Osped F Spaziani, UOC Radiol, Frosinone, Italy

[37] Fdn IRCCS Policlin S Matteo, Dept Radiol, Pavia, Italy

[38] Lausanne Univ, UniL, Fac Biol & Med, Lausanne, Switzerland

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | 2023年 / 24卷 / 04期

关键词：

heart failure; right ventricular dysfunction; cardiac magnetic resonance; heart failure hospitalization; ejection fraction; HEART-FAILURE; EJECTION FRACTION; DYSFUNCTION; PRESSURE;

D O I：

10.1093/ehjci/jeac124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF). Methods and results Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n = 2449). RVSD was defined as RV ejection fraction (RVEF) <45%. Kaplan-Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8 +/- 14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0 +/- 10.8. Median follow-up was 959 days (interquartile range: 560-1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio = 1.44; 95% CI [1.09-1.91]; P = 0.01). On subgroup analyses, the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHA III/IV, in LVEF <35% than in LVEF >= 35%, and in patients with renal dysfunction when compared to those with normal renal function. Conclusion RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.

引用

页码：472 / 482

页数：11

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