Novel insights about albumin in cardiovascular diseases: Focus on heart failure

被引：36

作者：

Zoanni, Beatrice ^{[1
]}

Brioschi, Maura ^{[1
]}

Mallia, Alice ^{[1
]}

Gianazza, Erica ^{[1
]}

Eligini, Sonia ^{[1
]}

Carini, Marina ^{[2
]}

Aldini, Giancarlo ^{[2
]}

Banfi, Cristina ^{[1
]}

机构：

[1] IRCCS, Ctr Cardiol Monzino, Milan, Italy

[2] Univ Milan, Dipartimento Sci Farmaceut, Milan, Italy

来源：

MASS SPECTROMETRY REVIEWS | 2023年 / 42卷 / 04期

关键词：

albumin; heart failure; oxidative stress; HUMAN-SERUM-ALBUMIN; ISCHEMIA-MODIFIED ALBUMIN; PROTEIN-TYROSINE NITRATION; LEVELS PREDICT SURVIVAL; STAGE RENAL-DISEASE; GLYCATED ALBUMIN; OXIDATIVE STRESS; HUMAN-PLASMA; MASS-SPECTROMETRY; SULFENIC ACID;

D O I：

10.1002/mas.21743

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The Human Plasma Proteome has always been the most investigated compartment in proteomics-based biomarker discovery, and is considered the largest and deepest version of the human proteome, reflecting the state of the body in health and disease. Even if efforts have been always dedicated to the refinement of proteomic approaches to investigate more deeply the plasma proteome, it should not be forgotten that also highly abundant plasma proteins, like human serum albumin (HSA), often neglected in these studies, might provide fundamental physiological functions in plasma, and should be better considered. This review summarizes the important roles of HSA in the context of cardiovascular diseases (CVD), and in particular in heart failure. Notwithstanding much attention has been historically directed toward the association of HSA levels and CVD risk, the advances in the field of mass spectrometry research allow also a better characterization of the effects of oxidative modifications that could alter not only the structure but also the function of HSA.

引用

页码：1113 / 1128

页数：16

共 108 条

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