Living myocardial slices: Advancing arrhythmia research

被引：8
作者：
Amesz, Jorik H. [1 ,2 ]
Zhang, Lu [2 ]
Everts, Bian R. [1 ]
De Groot, Natasja M. S. [2 ]
Taverne, Yannick J. H. J. [1 ]
机构：
[1] Erasmus MC, Lowlands Inst Bioelect Med, Dept Cardiothorac Surg, Translat Cardiothorac Surg Res Lab, Rotterdam, Netherlands
[2] Erasmus MC, Lowlands Inst Bioelect Med, Dept Cardiol, Translat Electrophysiol, Rotterdam, Netherlands
来源：
FRONTIERS IN PHYSIOLOGY | 2023年 / 14卷
关键词：
living myocardial slices; 3D cardiac models; cardiac arrhythmia models; in-vitro electrophysiology; translational research; CARDIAC ACTION-POTENTIALS; PATCH-CLAMP RECORDINGS; IN-VITRO; TISSUE-SLICES; TRANSMURAL HETEROGENEITY; REENTRANT ACTIVITY; HEART SLICES; SPIRAL WAVES; MODEL; EXCITATION;
D O I：
10.3389/fphys.2023.1076261
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Living myocardial slices (LMS) are ultrathin (150-400 mu m) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options.
引用
收藏
页数：9
相关论文
共 91 条
[1]  
Amesz J. H., 2022, RES SQUARE, DOI [10.21203/rs.3.rs-1799902/v1, DOI 10.21203/RS.3.RS-1799902/V1]
[2]   A Novel Approach to Dual Excitation Ratiometric Optical Mapping of Cardiac Action Potentials With Di-4-ANEPPS Using Pulsed LED Excitation [J].
Bachtel, Andrew D. ;
Gray, Richard A. ;
Stohlman, Jayna M. ;
Bourgeois, Elliot B. ;
Pollard, Andrew E. ;
Rogers, Jack M. .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2011, 58 (07) :2120-2126
[3]   Modelling diffusive O2 supply to isolated preparations of mammalian skeletal and cardiac muscle [J].
Barclay, CJ .
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2005, 26 (4-5) :225-235
[4]   Visualizing excitation waves inside cardiac muscle using transillumination [J].
Baxter, WT ;
Mironov, SF ;
Zaitsev, AV ;
Jalife, J ;
Pertsov, AM .
BIOPHYSICAL JOURNAL, 2001, 80 (01) :516-530
[5]  
Berenfeld Omer, 2019, Card Electrophysiol Clin, V11, P495, DOI [10.1016/j.ccep.2019.04.004, 10.1016/j.ccep.2019.04.004]
[6]   Age-related regulation and region-specific distribution of ion channel subunits promoting atrial fibrillation in human left and right atria [J].
Biliczki, Peter ;
Boon, Reinier A. ;
Girmatsion, Zenawit ;
Bukowska, Alicia ;
Ordog, Balazs ;
Kaess, Bernhard M. ;
Hohnloser, Stefan H. ;
Goette, Andreas ;
Varro, Andras ;
Moritz, Anton ;
Nattel, Stanley ;
Ehrlich, Joachim R. .
EUROPACE, 2019, 21 (08) :1261-1269
[7]   Animal Models to Study Cardiac Arrhythmias [J].
Blackwell, Daniel J. ;
Schmeckpeper, Jeffrey ;
Knollmann, Bjorn C. .
CIRCULATION RESEARCH, 2022, 130 (12) :1926-1964
[8]   Organotypic slice culture from human adult ventricular myocardium [J].
Brandenburger, Matthias ;
Wenzel, Jan ;
Bogdan, Roman ;
Richardt, Doreen ;
Nguemo, Filomain ;
Reppel, Michael ;
Hescheler, Juergen ;
Terlau, Heinrich ;
Dendorfer, Andreas .
CARDIOVASCULAR RESEARCH, 2012, 93 (01) :50-59
[9]   PATCH-CLAMP RECORDINGS ON RAT CARDIAC-MUSCLE SLICES [J].
BURNASHEV, NA ;
EDWARDS, FA ;
VERKHRATSKY, AN .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 417 (01) :123-125
[10]   Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties [J].
Bursac, N ;
Papadaki, M ;
White, JA ;
Eisenberg, SR ;
Vunjak-Novakovic, G ;
Freed, LE .
TISSUE ENGINEERING, 2003, 9 (06) :1243-1253
12345678910