New Chlorinated Metabolites and Antiproliferative Polyketone from the Mangrove Sediments-Derived Fungus Mollisia sp. SCSIO41409

被引：14

作者：

Cai, Jian ^{[1
,2
]}

Wang, Xueni ^{[1
,3
]}

Gan, Xia ^{[3
,4
]}

Zhou, Qian ^{[3
]}

Luo, Xiaowei ^{[4
]}

Yang, Bin ^{[1
,2
]}

Liu, Yonghong ^{[1
,2
]}

Ratnasekera, Disna ^{[5
]}

Zhou, Xuefeng ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Guangxi Univ Chinese Med, Guangxi Zhuang Yao Med Ctr Engn & Technol, Nanning 530200, Peoples R China

[4] Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China

[5] Univ Ruhuna, Fac Agr, Dept Agr Biol, Matara 81000, Sri Lanka

来源：

MARINE DRUGS | 2023年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

mangrove sediments-fungus; Mollisia sp; chlorinated metabolites; prostate cancer; antimicrobial; POTENTIATORS; STEMPHONES; CULTURES;

D O I：

10.3390/md21010032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new chlorinated metabolites, 8-chlorine-5-hydroxy-2,3-dimethyl-7-methoxychromone (1) and 3,4-dichloro-1H-pyrrole-2,5-dione (3), and eight known compounds (2 and 4-9) were isolated from the mangrove sediments-derived fungus Mollisia sp. SCSIO41409. Their structures were elucidated by physicochemical properties and extensive spectroscopic analysis. The absolute configuration of stemphone C (4) was established for the first time by the X-ray crystallographic analysis. Compounds 3 and 4 showed different intensity of antimicrobial activities against several pathogenic fungi and bacteria, and antiproliferative activities against two human prostate cancer cell lines (IC50 values 2.77 to 9.60 mu M). Further, stemphone C (4) showed a reducing PC-3 cell colony formation, inducing apoptosis and blocking the cell cycle at S-phase in a dose-dependent manner; thus, it could be considered as a potential antiproliferative agent and a promising anti-prostate cancer lead compound.

引用

页数：11

共 33 条

[1] Thiodiketopiperazines and Alkane Derivatives Produced by the Mangrove Sediment-Derived Fungus Penicillium ludwigii SCSIO 41408 [J].