The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review

被引：30
|
作者：
Xu, Jie [1 ]
Yu, Linxin [2 ]
Liu, Feng [1 ]
Wan, Longbiao [1 ]
Deng, Zhenhua [3 ]
机构：
[1] Wuhan Univ, Dept Orthoped, Renmin Hosp, Wuhan, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Wuhan, Peoples R China
[3] Hubei Prov Hosp Tradit Chinese Med TCM, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
osteoporosis; cytokine; osteoblasts; osteoclasts; bone remodeling; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; INHIBITS HUMAN OSTEOCLASTOGENESIS; COLLAGEN-INDUCED ARTHRITIS; COLONY-STIMULATING FACTOR; MESENCHYMAL STEM-CELLS; IFN-GAMMA PRODUCTION; FORMATION IN-VITRO; CD4(+) T-CELLS; RECEPTOR ACTIVATOR;
D O I：
10.3389/fimmu.2023.1222129
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology. In this field, cytokines that are among osteoblasts and osteoclasts play a critical role in bone remodeling, which is a pathological process in the pathogenesis and development of osteoporosis. Those cytokines include the tumor necrosis factor (TNF) family, the interleukin (IL) family, interferon (IFN), chemokines, and so on, most of which influence the bone microenvironment, osteoblasts, and osteoclasts. This review summarizes the effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis, aiming to providing the latest reference to the role of immunology in osteoporosis.
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页数：16
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