Non-lethal outcomes of engaging regulated cell death pathways in cancer

被引：24

作者：

Kalkavan, Halime ^{[1
,2
,3
]}

Ruehl, Sebastian ^{[1
,4
]}

Shaw, Jeremy J. P. ^{[1
]}

Green, Douglas R. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Univ Hosp Essen, West German Canc Ctr, Dept Med Oncol, Essen, Germany

[3] Partner Site Univ Hosp Essen, German Canc Consortium DKTK, Essen, Germany

[4] T3 Pharmaceut AG, Allschwil, Switzerland

来源：

NATURE CANCER | 2023年 / 4卷 / 06期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

NF-KAPPA-B; CYTOCHROME-C RELEASE; FATTY-ACID OXIDATION; DNA-DAMAGE; GENOMIC INSTABILITY; APOPTOSIS; RESISTANCE; ACTIVATION; INHIBITOR; THERAPY;

D O I：

10.1038/s43018-023-00571-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the engagement of RCD pathways does not inevitably result in cell death. Instead, RCD pathways can take part in diverse biological processes if the cells survive. Consequently, these surviving cells, for which we propose the term 'flatliners', harbor important functions. These evolutionarily conserved responses can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.

引用

页码：795 / 806

页数：12

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