Research Progress of Porcine Reproductive and Respiratory Syndrome Virus NSP2 Protein

被引：15

作者：

Liu, Benjin ^{[1
]}

Luo, Lingzhi ^{[1
]}

Shi, Ziqi ^{[1
]}

Ju, Houbin ^{[2
]}

Yu, Lingxue ^{[3
]}

Li, Guoxin ^{[3
]}

Cui, Jin ^{[1
]}

机构：

[1] Northeast Agr Univ, Coll Vet Med, Harbin 150038, Peoples R China

[2] Shanghai Anim Dis Prevent & Control Ctr, Shanghai 201103, Peoples R China

[3] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 12期

关键词：

PRRSV; NSP2; -2/-1 programmed ribosomal frameshifting; Interferon; autophagy; apoptosis; SYNDROME PRRS VIRUS; NONSTRUCTURAL PROTEIN-2; STRUCTURAL PROTEINS; NONESSENTIAL REGION; MONOCLONAL-ANTIBODY; RNA-SYNTHESIS; CELL-DEATH; REPLICATION; VIRULENCE; STRAIN;

D O I：

10.3390/v15122310

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine reproductive and respiratory syndrome virus (PRRSV) is globally prevalent and seriously harms the economic efficiency of pig farming. Because of its immunosuppression and high incidence of mutant recombination, PRRSV poses a great challenge for disease prevention and control. Nonstructural protein 2 (NSP2) is the most variable functional protein in the PRRSV genome and can generate NSP2N and NSP2TF variants due to programmed ribosomal frameshifts. These variants are broad and complex in function and play key roles in numerous aspects of viral protein maturation, viral particle assembly, regulation of immunity, autophagy, apoptosis, cell cycle and cell morphology. In this paper, we review the structural composition, programmed ribosomal frameshift and biological properties of NSP2 to facilitate basic research on PRRSV and to provide theoretical support for disease prevention and control and therapeutic drug development.

引用

页数：18

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