Structure of PD1 and its mechanism in the treatment of autoimmune diseases

被引：11

作者：

Rezayi, Mahdi ^{[1
]}

Hosseini, Arezoo ^{[2
]}

机构：

[1] Islamic Azad Univ, Dept Med Sci, Marand Baranch, Marand, Iran

[2] Urmia Univ Med Sci, Cellular & Mol Med Res Inst, Cellular & Mol Res Ctr, Orumiyeh, Iran

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2023年 / 41卷 / 07期

关键词：

anti-PD-1; therapy; autoimmunity; programmed cell death-1; rheumatoid arthritis; systemic lupus erythematosus; T cells; type; 1; diabetes; REGULATORY T-CELLS; PROGRAMMED DEATH-1 PD-1; SYSTEMIC-LUPUS-ERYTHEMATOSUS; WHITE)F-1 MICE PROMOTES; PROTEIN STABILITY; CHROMOSOMAL LOCALIZATION; VIRAL-INFECTION; SPLICE VARIANTS; PDCD1; GENE; EXPRESSION;

D O I：

10.1002/cbf.3827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PD-1 and CTLA-4 can play an important role in addressing the issue of autoimmune diseases. PD-1 is a transmembrane glycoprotein expressed on T, B, and Dentric cells. This molecule functions as a checkpoint in T cell proliferation. Ligation of PD-1 with its ligands inhibits the production of IL-2, IL-7, IL-10, and IL-12 as well as other cytokines by macrophages, natural killer (NK) cells, and T cells, which can suppress cell proliferation and inflammation. Today, scientists attempt to protect against autoimmune diseases by PD-1 inhibitory signals. In this review, we discuss the structure, expression, and signaling pathway of PD-1. In addition, we discuss the importance of PD-1 in regulating several autoimmune diseases, reflecting how manipulating this molecule can be an effective method in the immunotherapy of some autoimmune diseases.

引用

页码：726 / 737

页数：12

共 163 条

[1] The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice [J].

Ansari, MJI ;

Salama, AD ;

Chitnis, T ;

Smith, RN ;

Yagita, H ;

Akiba, H ;

Yamazaki, T ;

Azuma, M ;

Iwai, H ;

Khoury, SJ ;

Auchincloss, H ;

Sayegh, MH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) :63-69

[2] Regulation of PD-L1 Expression by NF-κB in Cancer [J].

Antonangeli, Fabrizio ;

Natalini, Ambra ;

Garassino, Marina Chiara ;

Sica, Antonio ;

Santoni, Angela ;

Di Rosa, Francesca .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[3]

Araki K, 2013, COLD SH Q B, V78, P239, DOI [10.1101/sqb.78.019869, 10.1101/sqb.2013.78.019869]

[4] Genetic and Epigenetic Regulation of PD-1 Expression [J].

Bally, Alexander P. R. ;

Austin, James W. ;

Boss, Jeremy M. .

JOURNAL OF IMMUNOLOGY, 2016, 196 (06) :2431-2437

[5] Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens A Systematic Review and Meta-analysis [J].

Barroso-Sousa, Romualdo ;

Barry, William T. ;

Garrido-Castro, Ana C. ;

Hodi, F. Stephen ;

Min, Le ;

Krop, Ian E. ;

Tolaney, Sara M. .

JAMA ONCOLOGY, 2018, 4 (02) :173-182

[6] PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes [J].

Ben Nasr, Moufida ;

Tezza, Sara ;

D'Addio, Francesca ;

Mameli, Chiara ;

Usuelli, Vera ;

Maestroni, Anna ;

Corradi, Domenico ;

Belletti, Silvana ;

Albarello, Luca ;

Becchi, Gabriella ;

Fadini, Gian Paolo ;

Schuetz, Christian ;

Markmann, James ;

Wasserfall, Clive ;

Zon, Leonard ;

Zuccotti, Gian Vincenzo ;

Fiorina, Paolo .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (416)

[7] Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade [J].

Blackburn, Shawn D. ;

Shin, Haina ;

Freeman, Gordon J. ;

Wherry, E. John .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) :15016-15021

[8] PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review [J].

Brody, Robert ;

Zhang, Yiduo ;

Ballas, Marc ;

Siddiqui, Mohd Kashif ;

Gupta, Palvi ;

Barker, Craig ;

Midha, Anita ;

Walker, Jill .

LUNG CANCER, 2017, 112 :200-215

[9] Role of PD-1 in regulating acute infections [J].

Brown, Keturah E. ;

Freeman, Gordon J. ;

Wherry, E. John ;

Sharpe, Arlene H. .

CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (03) :397-401

[10] T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes [J].

Burrack, Adam L. ;

Martinov, Tijana ;

Fife, Brian T. .

FRONTIERS IN ENDOCRINOLOGY, 2017, 8

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