REVIEW ON MULTIFACETED ANTICANCER ACTIVITY OF OCIMUM SANCTUM AND ITS CONSTITUENTS: PAST, PRESENT AND FUTURE

被引：0
作者：
Banerjee, Rahul [1 ]
Ghosh, Sudeepa [1 ]
Chowdhury, Avik Acharya [1 ]
机构：
[1] JIS Univ, Dept Biosci, 81 Nilgunj Rd, Kolkata 700109, W Bengal, India
来源：
SURANAREE JOURNAL OF SCIENCE AND TECHNOLOGY | 2023年 / 30卷 / 02期
关键词：
Anticancer properties; Cancer; Mechanism of action; Ocimum sanctum; OXIDATIVE STRESS; ROSMARINIC ACID; CARNOSIC ACID; HOLY BASIL; APOPTOSIS; APIGENIN; EXTRACT; GROWTH; LUNG; 7,12-DIMETHYLBENZ(A)ANTHRACENE;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ocimum sanctum Linn (OS), is the medicinal herb belonging to the Lamiaceae family, well-known as the 'Holi Basil' or 'Tulsi". It has been a part of ayurveda and Indian culture for its tremendous ethnomedicinal significance as it is employed to cure common cough and cold along with bronchitis, skin diseases, insect bite etc. The leaves of OS in particular are widely used for the treatment of cancer. Approximately 15 different types of biologically active chemicals have been extracted, purified and identified from this medicinal herb. The anticancer properties of the crude and purified products from OS have been studied extensively over decades. They showed tumor suppressive, radioprotective, chemo-preventive, anti-metastatic, anti-angiogenic and apoptotic effect on various types of cancer. This review summarizes the anticancer effect and mechanism of the purified products and extract obtained from OS on various cancers like breast, colon, lung, liver etc. The summarized report would help to fine-tune our understanding on the anti-cancer properties of OS that might open up new horizon in developing natural product-based cost-efficient cancer drug.
引用
收藏
页数：9
相关论文
共 52 条
[1]   Antitumor Initiating Potential of Rosmarinic Acid in 7,12-Dimethylbenz(a)anthracene-Induced Hamster Buccal Pouch Carcinogenesis [J].
Anusuya, Chezhiyan ;
Manoharan, Shanmugam .
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 2011, 30 (03) :199-211
[2]   ANTICARCINOGENIC EFFECTS OF SOME INDIAN PLANT-PRODUCTS [J].
ARUNA, K ;
SIVARAMAKRISHNAN, VM .
FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (11) :953-956
[3]   Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells [J].
Attoub, Samir ;
Hassan, Ahmed H. ;
Vanhoecke, Barbara ;
Iratni, Rabah ;
Takahashi, Takashi ;
Gaben, Anne-Marie ;
Bracke, Marc ;
Awad, Salma ;
John, Anne ;
Kamalboor, Hamda Ahmed ;
Al Sultan, Mahmood Ahmed ;
Arafat, Kholoud ;
Gespach, Christian ;
Petroianu, Georg .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 651 (1-3) :18-25
[4]   Ocimum Sanctum L (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer [J].
Baliga, Manjeshwar Shrinath ;
Jimmy, Rosmy ;
Thilakchand, Karadka Ramdas ;
Sunitha, Venkatesh ;
Bhat, Neeta Raghavendra ;
Saldanha, Elroy ;
Rao, Suresh ;
Rao, Pratima ;
Arora, Rajesh ;
Palatty, Princy L. .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 :26-35
[5]   Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells [J].
Baruah, Taranga Jyoti ;
Sharan, R. N. ;
Kma, Lakhan .
MOLECULAR BIOLOGY REPORTS, 2018, 45 (05) :1219-1225
[6]   Molecular and functional characterization of endophytic fungi from traditional medicinal plants [J].
Bhagat, Jyoti ;
Kaur, Amarjeet ;
Sharma, Madhunika ;
Saxena, A. K. ;
Chadha, B. S. .
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2012, 28 (03) :963-971
[7]   Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells [J].
Cai, Xueting ;
Ye, Tingmei ;
Liu, Chao ;
Lu, Wuguang ;
Lu, Min ;
Zhang, Juan ;
Wang, Min ;
Cao, Peng .
TOXICOLOGY IN VITRO, 2011, 25 (07) :1385-1391
[8]   Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts [J].
Chen, Di ;
Landis-Piwowar, Kristin R. ;
Chen, Marina S. ;
Dou, Q. Ping .
BREAST CANCER RESEARCH, 2007, 9 (06)
[9]  
Chen Q, 2012, NAT PROD COMMUN, V7, P29
[10]   Apigenin causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells [J].
Choi, Eun Jeong ;
Kim, Gun-Hee .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2009, 20 (04) :285-290
123456