Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus

被引：3

作者：

Gomez, Arianna Ericka ^{[1
,2
]}

Addish, Sumaya ^{[1
,2
]}

Alvarado, Kurtis ^{[1
,2
]}

Boatemaa, Priscilla ^{[1
,2
]}

Onyali, Anne C. C. ^{[1
,2
]}

Ramirez, Emily G. G. ^{[1
,2
]}

Rojas, Maria F. F. ^{[1
,2
]}

Rai, Jyoti ^{[1
,2
]}

Reynolds, Kiana A. A. ^{[1
,2
]}

Tang, W. Joyce ^{[1
,2
]}

Kwon, Ronald Young ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Orthopaed & Sports Med, Sch Med, Seattle, WA 98195 USA

[2] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA

来源：

CURRENT OSTEOPOROSIS REPORTS | 2023年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Genetics; Osteoporosis; GWAS; BMD; Fracture; WNT signaling; GENOME-WIDE; HUMAN WNT16; METAANALYSIS; MUSCLE; ILEI; MASS;

D O I：

10.1007/s11914-023-00783-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewChromosome region 7q31.31, also known as the CPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim of the review is to highlight experimental studies examining the function of genes at the CPED1-WNT16 locus.Recent FindingsGenes that reside at the CPED1-WNT16 locus include WNT16, FAM3C, ING3, CPED1, and TSPAN12. Experimental studies in mice strongly support the notion that Wnt16 is necessary for bone mass and strength. In addition, roles for Fam3c and Ing3 in regulating bone morphology in vivo and/or osteoblast differentiation in vitro have been identified. Finally, a role for wnt16 in dually influencing bone and muscle morphogenesis in zebrafish has recently been discovered, which has brought forth new questions related to whether the influence of WNT16 in muscle may conspire with its influence in bone to alter BMD and fracture risk.

引用

页码：173 / 183

页数：11

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