Associations of aortic stiffness and intra-aortic flow parameters with epicardial adipose tissue in patients with type-2 diabetes

被引:1
作者
Bouazizi, Khaoula [1 ,2 ]
Zarai, Mohamed [2 ]
Noufaily, Abdallah [3 ]
Prigent, Mikael [2 ]
Dietenbeck, Thomas [1 ,2 ]
Bollache, Emilie [1 ,2 ]
Nguyen, Toan [4 ]
Della Valle, Valeria [4 ]
Blondiaux, Eleonore [4 ]
Clement, Karine [5 ,6 ,7 ]
Aron-Wisnewsky, Judith [5 ,6 ,7 ]
Andreelli, Fabrizio [2 ,8 ]
Redheuil, Alban [1 ,2 ,3 ]
Kachenoura, Nadjia [1 ,2 ]
机构
[1] Sorbonne Univ, INSERM, CNRS, Lab Imagerie Biomed LIB, Paris, France
[2] Inst Cardiometab & Nutr ICAN, ICAN Imaging, Paris, France
[3] Hop La Pitie Salpetriere, Unite Imagerie Cardiovasc & Thorac ICT, Paris, France
[4] Armand Trousseau Hosp, AP HP, Radiol Dept, Paris, France
[5] Sorbonne Univ, INSERM, Nutr & Obes, Paris, France
[6] Sorbonne Univ, Pitie Salpetriere Hosp, Nutr Dept, Approches Syst NutriOmique, Paris, France
[7] Hop La Pitie Salpetriere, AP HP, Ctr Rech Nutr Humaine CRNH Ile de France, Nutr Dept, Paris, France
[8] Hop La Pitie Salpetriere, AP HP, Diabetol Dept, Paris, France
来源
FRONTIERS IN CLINICAL DIABETES AND HEALTHCARE | 2023年 / 4卷
基金
欧盟第七框架计划;
关键词
epicardiac adipose tissue; cardiovascular MRI; type; 2; diabetes; aortic flow; cardiometabolic disease; MIGRATION INHIBITORY FACTOR; ARTERIAL STIFFNESS; AUTOMATED QUANTIFICATION; CT ANGIOGRAPHY; FAT; ATHEROSCLEROSIS; THICKNESS; REFLECTS; MELLITUS; LINKING;
D O I
10.3389/fcdhc.2023.1106342
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: It has been shown that increased aortic stiffness is related to type-2 diabetes (T2D) which is considered as a risk factor for cardiovascular disease. Among other risk factors is epicardial adipose tissue (EAT) which is increased in T2D and is a relevant biomarker of metabolic severity and adverse outcome. Purpose: To assess aortic flow parameters in T2D patients as compared to healthy individuals and to evaluate their associations with EAT accumulation as an index of cardiometabolic severity in T2D patients. Materials and methods: Thirty-six T2D patients as well as 29 healthy controls matched by age and sex were included in this study. Participants had cardiac and aortic MRI exams at 1.5 T. Imaging sequences included cine SSFP for left ventricle (LV) function and EAT assessment and aortic cine and phase-contrast imaging for strain and flow parameters quantification. Results: In this study, we found LV phenotype to be characterized by concentric remodeling with decreased stroke volume index despite global LV mass within a normal range. EAT was increased in T2D patients compared to controls (p<0.0001). Moreover, EAT, a biomarker of metabolic severity, was negatively correlated to ascending aortic (AA) distensibility (p=0.048) and positively to the normalized backward flow volume (p=0.001). These relationships remained significant after further adjustment for age, sex and central mean blood pressure. In a multivariate model, presence/absence of T2D and AA normalized backward flow (BF) to forward flow (FF) volumes ratio are both significant and independent correlates of EAT. Conclusion: In our study, aortic stiffness as depicted by an increased backward flow volume and decreased distensibility seems to be related to EAT volume in T2D patients. This observation should be confirmed in the future on a larger population while considering additional biomarkers specific to inflammation and using a longitudinal prospective study design.
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页数:10
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