POCl3/Sulfoxide-Promoted Synthesis of Indolizino[8,7-b]indoles

被引：7

作者：

Chen, Xiao-Hui ^{[1
]}

Li, Yun-Meng ^{[1
]}

Huang, Xiang ^{[1
,2
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Coll Chem & Environm Engn, Lab Asymmetr Synth, Chongqing 402160, Peoples R China

[2] Chongqing Univ Sci & Technol, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 23期

基金：

中国国家自然科学基金;

关键词：

DIMETHYL-SULFOXIDE; DEAROMATIZATION STRATEGIES; POLYCYCLIC INDOLINES; ACID; CATALYST; CASCADE; CONSTRUCTION; BROMINATION; CYCLIZATION; ALKALOIDS;

D O I：

10.1021/acs.joc.3c01912

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild chlorocyclization of pyrrole-tethered indoles has been realized using POCl3 as the chlorine source and tetramethylene sulfoxide as the promoter. A variety of chlorinated indolizino-[8,7-b]-indole derivatives have been constructed efficiently under this reaction system in moderate to good yields (19 examples, up to 93% yield).

引用

页码：16400 / 16409

页数：10

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