In Vivo Studies of Medical Implants for Maxillofacial Surgery Produced from Nanostructured Titanium

被引：3

作者：

Matchin, Alexander A. ^{[1
]}

Nosov, Evgeniy V. ^{[1
]}

Stadnikov, Alexander A. ^{[2
]}

Klevtsov, Gennadiy V. ^{[3
]}

Rezyapova, Luiza R. ^{[4
]}

Sayapina, Natalia A. ^{[4
]}

Blinova, Elena V. ^{[2
]}

Valiev, Ruslan Z. ^{[4
]}

机构：

[1] Orenburg State Med Univ, Dept Dent & Maxillofacial Surg, Orenburg 460000, Russia

[2] Orenburg State Med Univ, Dept Histol Cytol & Embryol, Orenburg 460000, Russia

[3] Togliatti State Univ, Dept Nanotechnol Mat Sci & Mech, Tolyatti 445020, Russia

[4] Ufa Univ Sci & Technol, Inst Phys Adv Mat, Ufa 450076, Russia

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2023年 / 9卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

osseointegration; ultrafine-grained structure; titanium; nanostructured materials; medical implants; in vivo; PURE TITANIUM; TI; MICROSTRUCTURE;

D O I：

10.1021/acsbiomaterials.3c00813

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This paper presents the results of comprehensive in vivo studies into the osseointegration behavior of medical implants for maxillofacial surgery produced from nanostructured grade 4 titanium. Special attention is given to the phenomenology of bone tissue formation with consideration of its surface relief features and to evaluating the quantitative parameters of the morphological indicators of osteoblast and endothelial cells in the osseointegration zone. These parameters were compared with their measurement data for standard factory-made implants, and considerable acceleration in the fixation of nanotitanium implants due to osseointegation was found. The obtained results indicate a better osseointegration of implants made of nanotitanium in comparison to similar standard products.

引用

页码：6138 / 6145

页数：8

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