Design and synthesis of ?-Fe2O3@Ag-S-CH2-COOH nanocatalyst for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anti-skin cancer activity

被引：2

作者：

Gurav, Akshay Pandurang ^{[1
]}

Gurav, Rutikesh Pandit ^{[2
]}

Zond, Rutuja Ramesh ^{[1
]}

Satyanarayan, Nayak Devappa ^{[3
]}

Belur, Nippu Ningegowda ^{[3
]}

Hangirgekar, Shankar Poshatti ^{[1
,4
]}

机构：

[1] Shivaji Univ, Dept Chem, Kolhapur 416004, India

[2] D DY Patil Prathishthans Coll Engn, Dept Chem, Kolhapur 416001, India

[3] Kuvempu Univ, Dept Pharmaceut Chem, Chikkamagaluru 577451, India

[4] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2023年 / 37卷 / 06期

关键词：

2,3-dihydroquinazolin-4(1H)-ones; anti-skin cancer activity; molecular docking study; retrievable catalyst; gamma-Fe2O3@Ag-S-CH2-COOH nanocatalyst; REUSABLE CATALYST; EFFICIENT SYNTHESIS; DERIVATIVES; WATER; RUST;

D O I：

10.1002/aoc.7086

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The ongoing work describes the catalytic evaluation of ?-Fe2O3@Ag-S-CH2-COOH magnetic nanoparticles utilizing ?-Fe2O3 obtained from waste iron rust for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones. As-prepared ?-Fe2O3@Ag-S-CH2-COOH nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) technique. The catalytic performance of greener ?-Fe2O3@Ag-S-CH2-COOH nanoparticles was utilized in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones. The excellent catalytic performance was shown by magnetic nanoparticles in addition to its ease of separation by an external magnet and can be recycled for five consecutive turns without significant loss of catalytic activity. Furthermore, the synthesized 2,3-dihydroquinazolin-4(1H)-ones were confirmed by FT-IR, H-1, C-13 nuclear magnetic resonance (NMR), and mass spectrometry. Moreover, the synthesized 2,3-dihydroquinazolin-4(1H)-ones were evaluated for their anticancer efficiency against the human skin cancer cell line B16F10 along with molecular docking investigation.

引用

页数：19

共 62 条

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