LCN2: Versatile players in breast cancer

被引：13
作者：
Bao, Yuxiang [1 ]
Yan, Zhongliang [1 ]
Shi, Nianmei [2 ]
Tian, Xiaoyan [2 ]
Li, Jiayang [3 ]
Li, Taolang [1 ]
Cheng, Xiaoming [1 ]
Lv, Junyuan [1 ,4 ,5 ]
机构：
[1] Zunyi Med Univ, Dept Gen Surg, Affiliated Hosp, Zunyi 563099, Guizhou, Peoples R China
[2] Zunyi Med Univ, Clin Inst 1, Zunyi 563006, Guizhou, Peoples R China
[3] Zunyi Med Univ, Off Drug Clin Trial Inst, Affiliated Hosp, Zunyi 563099, Peoples R China
[4] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi 563000, Peoples R China
[5] Zunyi Med Univ, Joint Int Res Lab Ethnomed, Minist Educ, Zunyi 563000, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 171卷
基金：
中国国家自然科学基金;
关键词：
LCN2; Breast cancer; Oncogene; GELATINASE-ASSOCIATED LIPOCALIN; IN-VITRO; NGAL; CELL; EXPRESSION; GROWTH; GENE; ANGIOGENESIS; MACROPHAGES; METASTASIS;
D O I：
10.1016/j.biopha.2023.116091
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lipocalin 2 (LCN2) is a secreted glycoprotein that is produced by immune cells, including neutrophils and macrophages. It serves various functions such as transporting hydrophobic ligands across the cellular membrane, regulating immune responses, keeping iron balance, and fostering epithelial cell differentiation. LCN2 plays a crucial role in several physiological processes. LCN2 expression is upregulated in a variety of human diseases and cancers. High levels of LCN2 are specifically linked to breast cancer (BC) cell proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, chemotherapy resistance, and prognosis. As a result, LCN2 has gained attention as a potential therapeutic target for BC. This article offered an in-depth review of the advancement of LCN2 in the context of BC occurrence and development.
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页数：8
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