Comparative Pathology of Animal Models for Influenza A Virus Infection

被引:9
作者
Kirk, Natalie M. [1 ]
Liang, Yuying [1 ]
Ly, Hinh [1 ]
机构
[1] Univ Minnesota Twin Cities, Coll Vet Med, Dept Vet & Biomed Sci, Minneapolis, MN 55455 USA
关键词
respiratory pathogens; influenza virus; IAV; IBV; animal models; pathology; pathogenesis; RESPIRATORY-DISTRESS-SYNDROME; AVIAN-INFLUENZA; H5N1; VIRUSES; HONG-KONG; PANDEMIC INFLUENZA; MOUSE MODEL; CYNOMOLGUS-MACAQUES; PROTECTIVE IMMUNITY; TRANSMISSION MODEL; ENHANCED VIRULENCE;
D O I
10.3390/pathogens13010035
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Animal models are essential for studying disease pathogenesis and to test the efficacy and safety of new vaccines and therapeutics. For most diseases, there is no single model that can recapitulate all features of the human condition, so it is vital to understand the advantages and disadvantages of each. The purpose of this review is to describe popular comparative animal models, including mice, ferrets, hamsters, and non-human primates (NHPs), that are being used to study clinical and pathological changes caused by influenza A virus infection with the aim to aid in appropriate model selection for disease modeling.
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页数:21
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