Photoresponsive 'chemo-free' phytotherapy: formulation development for the treatment of triple-negative breast cancer

被引：2
作者：
Maheshwari, Neha [1 ]
Sharma, Mukesh C. [1 ]
机构：
[1] Devi Ahilya Vishwavidyalaya, Sch Pharm, Takshila Campus, Indore 452001, Madhya Pradesh, India
来源：
NANOMEDICINE | 2024年 / 19卷 / 01期
关键词：
IR780; photodynamic therapy; photothermal therapy; phytotherapy; plant extract; triple-negative breast cancer; PHOTOTHERMAL THERAPY; NANOPARTICLES; DELIVERY; CELLS;
D O I：
10.2217/nnm-2023-0231
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: The present investigation aimed to develop a chemo-free, nanophytosomal system to treat triple-negative breast cancer (TNBC) via a phyto-photo dual treatment strategy. Method: Size, shape, surface analysis, photoprovoked release profile, photothermal stability, (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay, apoptotic assay, DNA fragmentation, in vitro cellular uptake evaluation, mitochondrial membrane potential and caspase-3 assay, and photodynamic evaluation. Results: Biological experiments using MDA-MB-231 cells displayed dose-dependent synergistic anti-TNBC activity of PhytoS/Houttuynia cordata extract (HCE)/IR780 as compared with Phyto/HCE, PhytoS/IR780 and even more promising under laser treatment. Apoptotic assay and DNA fragmentation analysis also showed enhanced anti-TNBC effects. Investigation found that HCE acts via suppression of mitochondrial membrane potential and inducing caspase-3 activity in cells. Conclusion: Our findings suggested that photo-empowered phytotherapy can be employed effectively and safely against TNBC.
引用
收藏
页码：5 / 24
页数：20
相关论文
共 77 条
[11]  
Asati V., 2022, Int J Med Pharm Sci, V12, P1, DOI [10.31782/ijmps.2022.12301, DOI 10.31782/IJMPS.2022.12301]
[12]   Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets [J].
Asgharian, Parina ;
Tazekand, Abbas Pirpour ;
Hosseini, Kamran ;
Forouhandeh, Haleh ;
Ghasemnejad, Tohid ;
Ranjbar, Maryam ;
Hasan, Muzaffar ;
Kumar, Manoj ;
Beirami, Sohrab Minaei ;
Tarhriz, Vahideh ;
Soofiyani, Saiedeh Razi ;
Kozhamzharova, Latipa ;
Sharifi-Rad, Javad ;
Calina, Daniela ;
Cho, William C. .
CANCER CELL INTERNATIONAL, 2022, 22 (01)
[13]   Utility of Intravenous Curcumin Nanodelivery Systems for Improving In Vivo Pharmacokinetics and Anticancer Pharmacodynamics [J].
Bagheri, Mahsa ;
Nostrum, Cornelus F. van ;
Kok, Robbert Jan ;
Storm, Gert ;
Hennink, Wim E. ;
Heger, Michal .
MOLECULAR PHARMACEUTICS, 2022, 19 (09) :3057-3074
[14]   A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells [J].
Biswas, Partha ;
Dey, Dipta ;
Biswas, Polash Kumar ;
Rahaman, Tanjim Ishraq ;
Saha, Shuvo ;
Parvez, Anwar ;
Khan, Dhrubo Ahmed ;
Lily, Nusrat Jahan ;
Saha, Konka ;
Sohel, Md ;
Hasan, Mohammad Mehedi ;
Al Azad, Salauddin ;
Bibi, Shabana ;
Hasan, Md Nazmul ;
Rahmatullah, Mohammed ;
Chun, Jaemoo ;
Rahman, Md Ataur ;
Kim, Bonglee .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
[15]   Triple Negative Breast Cancer: Updates on Classification and Treatment in 2021 [J].
Bou Zerdan, Maroun ;
Ghorayeb, Tala ;
Saliba, Fares ;
Allam, Sabine ;
Bou Zerdan, Morgan ;
Yaghi, Marita ;
Bilani, Nadeem ;
Jaafar, Rola ;
Nahleh, Zeina .
CANCERS, 2022, 14 (05)
[16]   Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation [J].
Cantu, Travis ;
Walsh, Kyle ;
Pattani, Varun P. ;
Moy, Austin J. ;
Tunnell, James W. ;
Irvin, Jennifer A. ;
Betancourt, Tania .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 :615-632
[17]   Enhanced anticancer effect of quercetin microparticles formulation obtained by spray drying [J].
Caruana, Roberto ;
Montalbano, Francesco ;
Zizzo, Maria Grazia ;
Puleio, Roberto ;
Caldara, Gaetano ;
Cicero, Luca ;
Cassata, Giovanni ;
Licciardi, Mariano .
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2022, 57 (05) :2739-2746
[18]   Photodynamic therapy with the dual-mode association of IR780 to PEG-PLA nanocapsules and the effects on human breast cancer cells [J].
Carvalho Machado, Marina Guimaraes ;
de Oliveira, Maria Alice ;
Lanna, Elisa Gomes ;
Siqueira, Raoni Pais ;
Pound-Lana, Gwenaelle ;
Branquinho, Renata Tupinamba ;
Furtado Mosqueira, Vanessa Carla .
BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
[19]   Inhibiting the PI3K/AKT/mTOR signalling pathway with copper oxide nanoparticles from Houttuynia cordata plant: attenuating the proliferation of cervical cancer cells [J].
Chen, Hongmin ;
Feng, Xiaojie ;
Gao, Ling ;
Mickymaray, Suresh ;
Paramasivam, Anand ;
Alfaiz, Faiz Abdulaziz ;
Almasmoum, Hussain A. ;
Ghaith, Mazen M. ;
Almaimani, Riyad A. ;
Ibrahim, Ibrahim Abdel Aziz .
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2021, 49 (01) :240-249
[20]   Collective Plasmon Coupling in Gold Nanoparticle Clusters for Highly Efficient Photothermal Therapy [J].
Chen, Jinxing ;
Gong, Mingfu ;
Fan, Yulong ;
Feng, Ji ;
Han, Lili ;
Xin, Huolin L. ;
Cao, Muhan ;
Zhang, Qiao ;
Zhang, Dong ;
Lei, Dangyuan ;
Yin, Yadong .
ACS NANO, 2022, 16 (01) :910-920
12345678