Photoresponsive 'chemo-free' phytotherapy: formulation development for the treatment of triple-negative breast cancer

被引：2
作者：
Maheshwari, Neha [1 ]
Sharma, Mukesh C. [1 ]
机构：
[1] Devi Ahilya Vishwavidyalaya, Sch Pharm, Takshila Campus, Indore 452001, Madhya Pradesh, India
来源：
NANOMEDICINE | 2024年 / 19卷 / 01期
关键词：
IR780; photodynamic therapy; photothermal therapy; phytotherapy; plant extract; triple-negative breast cancer; PHOTOTHERMAL THERAPY; NANOPARTICLES; DELIVERY; CELLS;
D O I：
10.2217/nnm-2023-0231
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: The present investigation aimed to develop a chemo-free, nanophytosomal system to treat triple-negative breast cancer (TNBC) via a phyto-photo dual treatment strategy. Method: Size, shape, surface analysis, photoprovoked release profile, photothermal stability, (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay, apoptotic assay, DNA fragmentation, in vitro cellular uptake evaluation, mitochondrial membrane potential and caspase-3 assay, and photodynamic evaluation. Results: Biological experiments using MDA-MB-231 cells displayed dose-dependent synergistic anti-TNBC activity of PhytoS/Houttuynia cordata extract (HCE)/IR780 as compared with Phyto/HCE, PhytoS/IR780 and even more promising under laser treatment. Apoptotic assay and DNA fragmentation analysis also showed enhanced anti-TNBC effects. Investigation found that HCE acts via suppression of mitochondrial membrane potential and inducing caspase-3 activity in cells. Conclusion: Our findings suggested that photo-empowered phytotherapy can be employed effectively and safely against TNBC.
引用
收藏
页码：5 / 24
页数：20
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