Clinical trials of antibody drugs in the treatments of atopic dermatitis

被引：5

作者：

Zhou, Guihao ^{[1
]}

Huang, Yueyao ^{[1
]}

Chu, Ming ^{[1
]}

机构：

[1] Peking Univ, Sch Basic Med Sci, Dept Immunol, Natl Hlth Commiss NHC,Key Lab Med Immunol, Beijing, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2023年 / 10卷

基金：

中国国家自然科学基金;

关键词：

atopic dermatitis; antibody drugs; clinical trials; dupilumab; tralokinumab; DUPILUMAB TREATMENT; DOUBLE-BLIND; EFFICACY; MODERATE; SAFETY; PLACEBO; LEBRIKIZUMAB; NEMOLIZUMAB; OMALIZUMAB; CHILDREN;

D O I：

10.3389/fmed.2023.1229539

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atopic dermatitis (AD) is one of the most common, relapsing, chronic inflammatory skin disease, being regarded as a global health issue. Recent studies have shown that Th2 cell-mediated type 2 immunity plays a central role in AD. The type 2 inflammatory cytokines such as IL-4, IL-13, IL-22, IL-31, IL-17 and IL-5 mediate the pathogenesis of AD. A variety of antibody drugs targeting these cytokines have been developed to treat AD in clinics. Notably, several antibody drugs have exhibited high efficacy in treating atopic dermatitis in previous studies, demonstrating that they could be therapeutic methods for AD patients. Herein, we reviewed the clinical trials of antibody drugs in the treatment of AD, which provides a useful guideline for clinicians to treat patients with AD in clinics.

引用

页数：8

共 76 条

[1] Facial erythema in patients with atopic dermatitis treated with Dupilumab - a descriptive study of morphology and Aetiology [J].

Ahn, J. ;

Lee, D. H. ;

Na, C. H. ;

Shim, D. H. ;

Choi, Y. S. ;

Jung, H. J. ;

Simpson, E. L. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2022, 36 (11) :2140-2152

[2] Recent advances in atopic dermatitis [J].

Ahn, Kangmo ;

Kim, Byung Eui ;

Kim, Jihyun ;

Leung, Donald Y. M. .

CURRENT OPINION IN IMMUNOLOGY, 2020, 66 :14-21

[3]

Avena-Woods C, 2017, AM J MANAG CARE, V23, pS115

[4]

Barbarot S, 2022, J DERMATOL TREAT, V33, P266, DOI [10.1080/09546634.2020.1750550, 10.1093/geronb/gbaa068]

[5] Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis [J].

Beck, Lisa A. ;

Cork, Michael J. ;

Amagai, Masayuki ;

De Benedetto, Anna ;

Kabashima, Kenji ;

Hamilton, Jennifer D. ;

Rossi, Ana B. .

JID INNOVATIONS, 2022, 2 (05)

[6] Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis [J].

Beck, Lisa A. ;

Thaci, Diamant ;

Hamilton, Jennifer D. ;

Graham, Neil M. ;

Bieber, Thomas ;

Rocklin, Ross ;

Ming, Jeffrey E. ;

Ren, Haobo ;

Kao, Richard ;

Simpson, Eric ;

Ardeleanu, Marius ;

Weinstein, Steven P. ;

Pirozzi, Gianluca ;

Guttman-Yassky, Emma ;

Suarez-Farinas, Mayte ;

Hager, Melissa D. ;

Stahl, Neil ;

Yancopoulos, George D. ;

Radin, Allen R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (02) :130-139

[7]

Belliveau Paul P, 2005, MedGenMed, V7, P27

[8] Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab [J].

Brunner, Patrick M. ;

Pavel, Ana B. ;

Khattri, Saakshi ;

Leonard, Alexandra ;

Malik, Kunal ;

Rose, Sharon ;

On, Shelbi Jim ;

Vekaria, Anjali S. ;

Traidl-Hoffmann, Claudia ;

Singer, Giselle K. ;

Baum, Danielle ;

Gilleaudeau, Patricia ;

Sullivan-Whalen, Mary ;

Fuentes-Duculan, Judilyn ;

Li, Xuan ;

Zheng, Xiuzhong ;

Estrada, Yeriel ;

Garcet, Sandra ;

Wen, Huei-Chi ;

Gonzalez, Juana ;

Coats, Israel ;

Cueto, Inna ;

Neumann, Avidan U. ;

Lebwohl, Mark G. ;

Krueger, James G. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (01) :142-154

[9] Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial [J].

Chan, Susan ;

Cornelius, Victoria ;

Cro, Suzie ;

Harper, John I. ;

Lack, Gideon .

JAMA PEDIATRICS, 2020, 174 (01) :29-37

[10] Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis [J].

Chen, Yi-Ling ;

Gutowska-Owsiak, Danuta ;

Hardman, Clare S. ;

Westmoreland, Melanie ;

MacKenzie, Teena ;

Cifuentes, Liliana ;

Waithe, Dominic ;

Lloyd-Lavery, Antonia ;

Marquette, Allison ;

Londei, Marco ;

Ogg, Graham .

SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (515)

← 1 2 3 4 5 6 7 8 →