SOHO State of the Art Updates and Next Questions |Treatment Approaches for Nodular Lymphocyte-Predominant Hodgkin Lymphoma

被引:1
作者
Binkley, Michael S. [1 ,3 ]
Advani, Ranjana H. [2 ]
机构
[1] Stanford Univ, Dept Radiat Oncol, Palo Alto, CA USA
[2] Stanford Univ, Dept Med, Div Oncol, Palo Alto, CA USA
[3] Stanford Univ, Dept Radiat Oncol, 875 Blake Wilbur Dr, Palo Alto, CA 94305 USA
关键词
Management; Hodgkin lymphoma; Adolescents; Young adults; BONE-MARROW INVOLVEMENT; LONG-TERM; RADIATION-THERAPY; TRANSFORMATION; CHEMOTHERAPY; RADIOTHERAPY; CHILDREN; OUTCOMES; SOCIETY; IMPACT;
D O I
10.1016/j.clml.2023.03.014
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare variant of Hodgkin lymphoma characterized by a persistent risk of relapse but an excellent overall survival. Historically, it was treated similarly to classic Hodgkin lymphoma, but efforts have been made to deintensify treatment due to risk of late toxicity associated with intensive therapy. For patients with completely resected stage IA NLPHL, no further treatment may be considered, particularly for pediatric patients. For those with stage I-II NLPHL without risk factors such as B symptoms, sites > 2, or variant pattern histology, lower intensity treatment with radiotherapy or chemotherapy alone may be sufficient. However, combined modality therapy is a standard treatment for favorable and unfavorable risk stage I-II NLPHL associated with excellent progression-free and overall survival rates. For patients with advanced stage NLPHL, the optimal chemotherapy is not defined, but R-CHOP appears to be an effective treatment. Efforts to study NLPHL through multicenter collaborative efforts are crucial to develop evidence based and individualized treatments for patients with NLPHL.
引用
收藏
页码:471 / 476
页数:6
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