Nonsteroidal Anti-inflammatory Drug (NSAID) Tolerance After Biological Therapy in Patients With NSAID-Exacerbated Respiratory Disease: A Randomized Comparative Trial

被引：15
作者：
Sanchez, Jorge [1 ,4 ]
Garcia, Elizabeth [2 ]
Lopez, Juan-Felipe [1 ]
Calle, Ana [1 ]
Buendia, Jefferson-Antonio [3 ]
机构：
[1] Univ Antioquia, Hosp Alma Mater Antioquia, Grp Clin & Expt Allergy GACE, Medellin, Colombia
[2] Surg Med Unit Otorhinolaryngol UNIMEQ ORL, Bogota, Colombia
[3] Univ Antioquia, Sch Med, Dept Pharmacol & Toxicol, Res Grp Pharmacol & Toxicol INFARTO, Medellin, Colombia
[4] Univ Antioquia, Allergol Dept, Cra 27 37 B Sur 69, Medellin, Colombia
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 07期
关键词：
ASPIRIN DESENSITIZATION; NASAL POLYPOSIS; CHRONIC RHINOSINUSITIS; OMALIZUMAB TREATMENT; ASTHMA; EFFICACY; SAFETY; METAANALYSIS; PREVALENCE; IMPACT;
D O I：
10.1016/j.jaip.2023.04.033
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
after 6 months of each biological therapy (intragroup comparisons). As exploratory outcomes, we compared NSAID tolerance between biological therapies (intergroup RESULTS: A total of 38 subjects were included; 9 received omalizumab. There was an increase in the concentration needed to produce a reaction during ASA-OCT with omalizumab (P < .001) and dupilumab (P 1/4 .004) but not with mepolizumab and frequency of NSAID tolerance (omalizumab 60%, dupilumab increased ASA tolerance, whereas mepolizumab and benralizu
引用
收藏
页码：2172 / 2179
页数：8
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