Revisiting of TAMs in tumor immune microenvironment: Insight from NF-?B signaling pathway

被引：19
作者：
He, Rui [1 ]
He, Yan [1 ]
Du, Ran [3 ]
Liu, Chenxin [1 ]
Chen, Zeran [1 ]
Zeng, Anqi [2 ]
Song, Linjiang [1 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Sichuan, Peoples R China
[2] Sichuan Acad Chinese Med Sci, Inst Translat Pharmacol & Clin Applicat, Chengdu 610041, Sichuan, Peoples R China
[3] Chengdu Normal Univ, Coll Educ & Psychol, Chengdu 611130, Sichuan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷
关键词：
Tumor-associated macrophages; NF-& kappa; B; MicroRNAs; Tumor immune microenvironment; KAPPA-B; HEPATOCELLULAR-CARCINOMA; MACROPHAGE POLARIZATION; CELL-PROLIFERATION; INNATE IMMUNITY; UP-REGULATION; STEM-CELLS; CANCER; INFLAMMATION; METASTASIS;
D O I：
10.1016/j.biopha.2023.115090
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Tumor-associated macrophages (TAMs) are key components of tumor immune microenvironment and play a dual role in promoting tumor growth and anti-tumor immunity. Therefore, regulating TAMs has become a promising method in cancer immunotherapy. NF- ?B pathway is the key regulatory pathway of TAMs. Targeting this pathway has shown the potential to improve tumor immune microenvironment. At present, there are still some controversies and the idea of combined therapy in this field. This article reviews the progress in the field of immunotherapy in improving tumor immune microenvironment by exploring the mechanism of regulating TAMs (including promoting M1 polarization, inhibiting M2 polarization and regulating TAMs infiltration).
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页数：11
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