Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response

被引:4
作者
Nozaki, Satoshi [1 ,2 ]
Nakatani, Yuka [1 ]
Mawatari, Aya [3 ]
Shibata, Nina [3 ]
Hume, William E. [2 ]
Hayashinaka, Emi [1 ]
Wada, Yasuhiro [1 ]
Doi, Hisashi [3 ]
Watanabe, Yasuyoshi [1 ]
机构
[1] RIKEN Ctr Biosyst Dynam Res, Lab Pathophysiol & Hlth Sci, 6 7 3 Minatojima Minamimachi, Chuo Ku, Kobe, Hyogo 6500047, Japan
[2] RIKEN Innovat Ctr, Novel PET Diagnost Lab, Kobe, Hyogo, Japan
[3] RIKEN Ctr Biosyst Dynam Res, Lab Labeling Chem, Kobe, Hyogo, Japan
关键词
ACID TRANSPORTER 1; POSITRON-EMISSION-TOMOGRAPHY; CANCER; TUMOR; EXPRESSION; METABOLISM; CARCINOMA; PITFALLS; HYPOXIA; GROWTH;
D O I
10.1038/s41598-023-29166-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Several limitations of [F-18]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [C-11]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targets have been actively developed. [F-18]FIMP was found to be highly accumulated in LAT1-positive tumors but not in inflamed tissue. The aim of this study was to explore whether [F-18]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with those of [C-11]MET and [F-18]FDG. Tumor uptake of [F-18]FIMP decreased at day 1 after irradiation, and remained low until day 14. Comparatively, that of [F-18]FDG initially decreased at day 3 but was transiently elevated at day 7 and then decreased again at day 10. Decreased tumor uptake of [C-11]MET was observed at day 10. In line with the uptake of [F-18]FIMP, the ratio of Ki-67 immuno-positive cells in tumor tissues significantly decreased at day 1, 7, and 10 as compared with that in the control. These findings suggest that [F-18]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, although further clarification is needed.
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页数:9
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