Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets

被引：4

作者：

Guan, Lizheng ^{[1
]}

Zhong, Gongxun ^{[1
]}

Fan, Shufang ^{[1
]}

Plisch, Erin M. ^{[1
]}

Presler, Robert ^{[1
]}

Gu, Chunyang ^{[1
]}

Babujee, Lavanya ^{[1
]}

Pattinson, David ^{[1
]}

Le Khanh Nguyen, Hang ^{[2
]}

Hoang, Vu Mai Phuong ^{[2
]}

Le, Mai Quynh ^{[2
]}

van Bakel, Harm ^{[3
]}

Neumann, Gabriele ^{[1
]}

Kawaoka, Yoshihiro ^{[1
,4
,5
,6
,7
]}

机构：

[1] Univ Wisconsin, Influenza Res Inst, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53711 USA

[2] Natl Inst Hyg & Epidemiol, Hanoi 100000, Vietnam

[3] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[4] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo 1088639, Japan

[5] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo 1088639, Japan

[6] Res Ctr Global Viral Dis, Natl Ctr Global Hlth & Med, Tokyo 1628655, Japan

[7] Univ Tokyo, Infect & Adv Res UTOPIA Ctr, Pandem Preparedness, Tokyo 1088639, Japan

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 05期

关键词：

influenza virus; H5; surveillance; Vietnam; deep sequencing; mice; AMINO-ACID-RESIDUES; A VIRUS; POULTRY MARKETS; RECEPTOR-BINDING; POLYMERASE-ACTIVITY; NS1; PROTEIN; A(H1N1)PDM09 VIRUS; MOLECULAR-BASIS; PANDEMIC H1N1; VIRULENCE;

D O I：

10.3390/v15051093

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Routine surveillance in live poultry markets in the northern regions of Vietnam from 2016 to 2017 resulted in the isolation of 27 highly pathogenic avian H5N1 and H5N6 viruses of 3 different clades (2.3.2.1c, 2.3.4.4f, and 2.3.4.4g). Sequence and phylogenetic analysis of these viruses revealed reassortment with various subtypes of low pathogenic avian influenza viruses. Deep-sequencing identified minor viral subpopulations encoding variants that may affect pathogenicity and sensitivity to antiviral drugs. Interestingly, mice infected with two different clade 2.3.2.1c viruses lost body weight rapidly and succumbed to virus infection, whereas mice infected with clade 2.3.4.4f or 2.3.4.4g viruses experienced non-lethal infections.

引用

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