Endocrine side effects of immune checkpoint inhibitors

被引：20
作者：
Cardona, Zulma [1 ]
Sosman, Jeffrey A. [2 ]
Chandra, Sunandana [2 ]
Huang, Wenyu [1 ]
机构：
[1] Northwestern Univ, Div Endocrinol Metab & Mol Med, Feinberg Sch Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Div Hematol & Oncol, Feinberg Sch Med, Chicago, IL USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
关键词：
immune checkpoint inhibitor (ICI); endocrine side effects; hypophysitis; thyroiditis; type1; diabetes; adrenalitis; adrenal insufficiency; central diabetes insipidus; IPILIMUMAB-INDUCED HYPOPHYSITIS; CELL LUNG-CANCER; QUALITY-OF-LIFE; ADVERSE EVENTS; RETROSPECTIVE ANALYSIS; ADRENAL INSUFFICIENCY; THYROID ANTIBODIES; PD-1; EXPRESSION; NIVOLUMAB; MANAGEMENT;
D O I：
10.3389/fendo.2023.1157805
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immune checkpoint inhibitors (ICIs) have increasingly been the mainstay of treatment for numerous malignancies. However, due to their association with autoimmunity, ICIs have resulted in a variety of side effects that involve multiple organs including the endocrine system. In this review article, we describe our current understanding of the autoimmune endocrinopathies as a result of the use of ICIs. We will review the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of the most commonly encountered endocrinopathies, including thyroiditis, hypophysitis, Type 1 diabetes, adrenalitis, and central diabetes insipidus.
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页数：12
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