Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques

被引：8

作者：

Yu, Jingyou ^{[1
]}

Thomas, Paul V. ^{[2
,3
]}

Sciacca, Michaela ^{[1
]}

Wu, Cindy ^{[1
]}

Liu, Jinyan ^{[1
]}

He, Xuan ^{[1
]}

Miller, Jessica ^{[1
]}

Hachmann, Nicole P. ^{[1
]}

Surve, Nehalee ^{[1
]}

McMahan, Katherine ^{[1
]}

Jacob-Dolan, Catherine ^{[1
,2
,3
]}

Powers, Olivia ^{[1
]}

Hall, Kevin ^{[1
]}

Barrett, Julia ^{[1
]}

Hope, David ^{[1
]}

Mazurek, Camille R. ^{[1
]}

Murdza, Tetyana ^{[1
]}

Chang, William C. ^{[2
]}

Golub, Emily ^{[2
,3
]}

Rees, Phyllis A. ^{[2
,3
]}

Peterson, Caroline E. ^{[2
,3
]}

Hajduczki, Agnes ^{[2
,3
]}

Chen, Wei-Hung ^{[2
,3
]}

Martinez, Elizabeth J. ^{[2
,3
]}

Hussin, Elizabeth ^{[2
,3
]}

Lange, Camille ^{[2
,3
]}

Gong, Hua ^{[8
]}

Matyas, Gary R. ^{[8
]}

Rao, Mangala ^{[8
]}

Suthar, Mehul ^{[6
]}

Boursiquot, Mona ^{[7
]}

Cook, Anthony ^{[7
]}

Pessaint, Laurent ^{[7
]}

Lewis, Mark G. ^{[7
]}

Andersen, Hanne ^{[7
]}

Bolton, Diane L. ^{[3
,8
]}

Michael, Nelson L. ^{[9
]}

Joyce, M. Gordon ^{[2
,3
]}

Modjarrad, Kayvon ^{[2
]}

Barouch, Dan H. ^{[1
,4
,5
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Walter Reed Army Inst Res WRAIR, Emerging Infect Dis Branch, Silver Spring, MD 20910 USA

[3] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD 20817 USA

[4] Ragon Inst MGH, MIT & Harvard, Cambridge, MA 02139 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Emory Univ, Atlanta, GA USA

[7] Bioqual, Rockville, MD USA

[8] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[9] Walter Reed Army Inst Res WRAIR, Ctr Infect Dis Res, Silver Spring, MD 20910 USA

来源：

CELL REPORTS MEDICINE | 2023年 / 4卷 / 04期

基金：

美国国家卫生研究院;

关键词：

antibody; B cell; BA.5; macaque; Omicron; SARS-CoV-2; T cell; vaccine;

D O I：

10.1016/j.xcrm.2023.101018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines demonstrate reduced protection against acquisition of BA.5 subvariant but are still effective against severe disease. However, immune corre-lates of protection against BA.5 remain unknown. We report the immunogenicity and protective efficacy of vaccine regimens consisting of the vector-based Ad26.COV2.S vaccine and the adjuvanted spike ferritin nanoparticle (SpFN) vaccine against a high-dose, mismatched Omicron BA.5 challenge in macaques. The SpFNx3 and Ad26 + SpFNx2 regimens elicit higher antibody responses than Ad26x3, whereas the Ad26 + SpFNx2 and Ad26x3 regimens induce higher CD8 T cell responses than SpFNx3. The Ad26 + SpFNx2 regimen elicits the highest CD4 T cell responses. All three regimens suppress peak and day 4 viral loads in the respi-ratory tract, which correlate with both humoral and cellular immune responses. This study demonstrates that both homologous and heterologous regimens involving Ad26.COV2.S and SpFN vaccines provide robust protection against a mismatched BA.5 challenge in macaques.

引用

页数：15

共 31 条

[1] Covid-19 Vaccines - Immunity, Variants, Boosters [J].

Barouch, Dan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (11) :1011-1020

[2] Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination [J].

Barouch, Dan H. ;

Stephenson, Kathryn E. ;

Sadoff, Jerald ;

Yu, Jingyou ;

Chang, Aiquan ;

Gebre, Makda ;

McMahan, Katherine ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Patel, Shivani ;

Le Gars, Mathieu ;

de Groot, Anne M. ;

Heerwegh, Dirk ;

Struyf, Frank ;

Douoguih, Macaya ;

van Hoof, Johan ;

Schuitemaker, Hanneke .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (10) :951-953

[3]

Barouch DH, 2018, LANCET, V392, P232, DOI [10.1016/S0140-6736(18)31364-3, 10.1016/s0140-6736(18)31364-3]

[4] Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate [J].

Beck, Zoltan ;

Matyas, Gary R. ;

Alving, Carl R. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2015, 1848 (03) :775-780

[5]

CDC_Data_Tracker, 2022, RAT LAB CONF COVID 1

[6] Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines [J].

Collier, Ai-ris Y. ;

Yu, Jingyou ;

McMahan, Katherine ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Maron, Jenny S. ;

Atyeo, Caroline ;

Martinez, David R. ;

Ansel, Jessica L. ;

Aguayo, Ricardo ;

Rowe, Marjorie ;

Jacob-Dolan, Catherine ;

Sellers, Daniel ;

Barrett, Julia ;

Ahmad, Kunza ;

Anioke, Tochi ;

VanWyk, Haley ;

Gardner, Sarah ;

Powers, Olivia ;

Bondzie, Esther A. ;

Wan, Huahua ;

Baric, Ralph S. ;

Alter, Galit ;

Hacker, Michele R. ;

Barouch, Dan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (21) :2010-2012

[7] Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus Macaques [J].

Dagotto, Gabriel ;

Mercado, Noe B. ;

Martinez, David R. ;

Hou, Yixuan J. ;

Nkolola, Joseph P. ;

Carnahan, Robert H. ;

Crowe, James E. ;

Baric, Ralph S. ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2021, 95 (08)

[8] Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection [J].

Feng, Shuo ;

Phillips, Daniel J. ;

White, Thomas ;

Sayal, Homesh ;

Aley, Parvinder K. ;

Bibi, Sagida ;

Dold, Christina ;

Fuskova, Michelle ;

Gilbert, Sarah C. ;

Hirsch, Ian ;

Humphries, Holly E. ;

Jepson, Brett ;

Kelly, Elizabeth J. ;

Plested, Emma ;

Shoemaker, Kathryn ;

Thomas, Kelly M. ;

Vekemans, Johan ;

Villafana, Tonya L. ;

Lambe, Teresa ;

Pollard, Andrew J. ;

Voysey, Merryn .

NATURE MEDICINE, 2021, 27 (11) :2032-+

[9] Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant [J].

Gao, Yu ;

Cai, Curtis ;

Grifoni, Alba ;

Muller, Thomas R. ;

Niessl, Julia ;

Olofsson, Anna ;

Humbert, Marion ;

Hansson, Lotta ;

Osterborg, Anders ;

Bergman, Peter ;

Chen, Puran ;

Olsson, Annika ;

Sandberg, Johan K. ;

Weiskopf, Daniela ;

Price, David A. ;

Ljunggren, Hans-Gustaf ;

Karlsson, Annika C. ;

Sette, Alessandro ;

Aleman, Soo ;

Buggert, Marcus .

NATURE MEDICINE, 2022, 28 (03) :472-+

[10] Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial [J].

Gilbert, Peter B. ;

Montefiori, David C. ;

McDermott, Adrian ;

Fong, Youyi ;

Benkeser, David ;

Deng, Weiping ;

Zhou, Honghong ;

Houchens, Christopher R. ;

Martins, Karen ;

Jayashankar, Lakshmi ;

Castellino, Flora ;

Flach, Britta ;

Lin, Bob C. ;

O'Connell, Sarah ;

McDanal, Charlene ;

Eaton, Amanda ;

Sarzotti-Kelsoe, Marcella ;

Lu, Yiwen ;

Yu, Chenchen ;

Borate, Bhavesh ;

van der Laan, Lars W. P. ;

Hejazi, Nima ;

Huynh, Chuong ;

Miller, Jacqueline ;

El Sahly, Hana M. ;

Baden, Lindsey R. ;

Baron, Mira ;

De la Cruz, Luis ;

Gay, Cynthia ;

Kalams, Spyros ;

Kelley, Colleen F. ;

Andrasik, Michele P. ;

Kublin, James G. ;

Corey, Lawrence ;

Neuzil, Kathleen M. ;

Carpp, Lindsay N. ;

Pajon, Rolando ;

Follmann, Dean ;

Donis, Ruben O. ;

Koup, Richard A. .

SCIENCE, 2022, 375 (6576) :43-+

← 1 2 3 4 →