Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids

被引：20

作者：

Wang, Shixu ^{[1
]}

Xu, Chongchong ^{[1
]}

Liu, Hongyan ^{[2
]}

Wei, Wei ^{[1
]}

Zhou, Xuemei ^{[1
]}

Qian, Haipeng ^{[3
]}

Zhou, Li ^{[2
]}

Zhang, Haiqing ^{[2
]}

Wu, Li ^{[2
]}

Zhu, Chen ^{[4
]}

Yang, Yuting ^{[5
]}

He, Lin ^{[2
]}

Li, Kuan ^{[1
,6
]}

机构：

[1] Kunming Med Univ, Sch Forens Med, Kunming, Yunnan, Peoples R China

[2] Kunming Med Univ, Mental Hosp Yunnan Prov, Mental Hlth Ctr, Kunming, Yunnan, Peoples R China

[3] AnHui Coll Tradit Chinese Med, Dept Nursing, Wuhu, Anhui, Peoples R China

[4] Kunming Med Univ, Dept Phys Educ, Kunming, Yunnan, Peoples R China

[5] Nanninng Normal Univ, Comp Sci & Technol Dept Sci & Engn, Shiyuan Coll, Nanning, Guangxi, Peoples R China

[6] Southern Med Univ, Sch Forens Med, Guangzhou, Guangdong, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 08期

关键词：

Gut Microbiota; Bile Acids; Alzheimer's Diseases; Parkinson's Diseases; Neurological and Endocrine; Immunity; FARNESOID X RECEPTOR; TAUROURSODEOXYCHOLIC ACID; COGNITIVE IMPAIRMENT; EXPERIMENTAL-MODELS; PARKINSONS-DISEASE; INDUCED APOPTOSIS; PATHWAY; METABOLISM; INHIBITION; TUDCA;

D O I：

10.1007/s12035-023-03340-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With the acceleration of global population aging, neurodegenerative diseases (NDs) will become the second leading cause of death in the world, which seriously threatens human life and health. Alzheimer's disease and Parkinson's disease are the most common and typical NDs. The exact mechanisms of the NDs occurrence and development remain unclear, which may be related to immune, oxidative stress, and abnormal aggregation of pathogenic proteins. Studies have suggested that gut microbiota (GM) influences brain function and plays an important role in regulating emotional and cognitive function. Recently, bile acids (BAs) have become the "star molecule" in the microbiota-gut-brain (MGB) axis research. BAs have been reported to exert anti-inflammatory, antioxidant, and neuroprotective activities in NDs. However, the role of BAs in the connection between GM and the central nervous system (CNS) is still unclear. In this review, we will review the possible mechanisms of BAs between GM and NDs and explore the function of BAs to provide ideas for the prevention and treatment of NDs in the future.

引用

页码：4618 / 4640

页数：23

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