Epithelial-mesenchymal transition

被引：0

作者：

Kubik, Joanna ^{[1
]}

Pawlak, Kamil ^{[1
]}

机构：

[1] Med Univ Lublin, Independent Med Biol Unit, Lublin, Poland

来源：

CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES | 2023年 / 36卷 / 01期

关键词：

epithelial-mesenchymal transition; cancer metastasis; circulating tumor cells; epithelial markers;

D O I：

10.2478/cipms-2023-0005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The process of epithelial-mesenchymal transition (EMT) occurs in both physiological and pathological states, and there are increasing links between EMT and tumor progression. During this process, dynamic changes in cell organization and function occur that promote migration and invasion. A better understanding of the mechanism of plastic EMT may help develop novel targeted therapies that can help treat cancers of varying degrees of malignancy. Our review helps to systematize knowledge of the molecular and biochemical mechanisms involved in the EMT process in both tumor and physiological backgrounds.

引用

页码：18 / 20

页数：3

共 15 条

[1]

Couchman JR, 2001, INT REV CYTOL, V207, P113

[2] Are 90% of deaths from cancer caused by metastases? [J].

Dillekas, Hanna ;

Rogers, Michael S. ;

Straume, Oddhjorn .

CANCER MEDICINE, 2019, 8 (12) :5574-5576

[3] EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis [J].

Genna, Anthony ;

Vanwynsberghe, Aline M. ;

Villard, Amelie V. ;

Pottier, Charles ;

Ancel, Julien ;

Polette, Myriam ;

Gilles, Christine .

CANCERS, 2020, 12 (06) :1-38

[4] Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications [J].

Jie, Xiao-Xiang ;

Zhang, Xiao-Yan ;

Xu, Cong-Jian .

ONCOTARGET, 2017, 8 (46) :81558-81571

[5] The basics of epithelial-mesenchymal transition [J].

Kalluri, Raghu ;

Weinberg, Robert A. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1420-1428

[6] In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation [J].

Kim, Kwang-Jin ;

Lee, Yong-Jin ;

Hwang, Yun-Ho ;

Kang, Kyung-Yun ;

Yee, Sung-Tae ;

Son, Young-Jin .

JOURNAL OF CLINICAL MEDICINE, 2017, 6 (03)

[7] Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT [J].

Li, Bifei ;

Shen, Weiyu ;

Peng, Huayi ;

Li, Yumei ;

Chen, Fan ;

Zheng, Liping ;

Xu, Jianhua ;

Jia, Lee .

ONCOTARGETS AND THERAPY, 2019, 12 :3207-3221

[8] Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis [J].

Marconi, Guya D. ;

Fonticoli, Luigia ;

Rajan, Thangavelu Soundara ;

Pierdomenico, Sante D. ;

Trubiani, Oriana ;

Pizzicannella, Jacopo ;

Diomede, Francesca .

CELLS, 2021, 10 (07)

[9] Inflammation and EMT: an alliance towards organ fibrosis and cancer progression [J].

Miguel Lopez-Novoa, Jose ;

Angela Nieto, M. .

EMBO MOLECULAR MEDICINE, 2009, 1 (6-7) :303-314

[10] Roles for E-cadherin cell surface regulation in cancer [J].

Petrova, Yuliya I. ;

Schecterson, Leslayann ;

Gumbiner, Barry M. .

MOLECULAR BIOLOGY OF THE CELL, 2016, 27 (21) :3233-3244

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