Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On-Demand Removability for Wound Closure and MRSA-Infected Wound Healing

被引：57

作者：

Kang, Xinchang ^{[1
]}

Guan, Pengfei ^{[1
,2
]}

Xiao, Cairong ^{[3
]}

Liu, Can ^{[4
]}

Guan, Youjun

Lin, Yeying ^{[1
]}

Tian, Yu ^{[1
]}

Ren, Kunyu ^{[1
]}

Huang, Yanting ^{[1
]}

Fu, Rumin ^{[3
]}

Ning, Chengyun ^{[3
]}

Fan, Lei ^{[5
]}

Tan, Guoxin ^{[1
]}

Zhou, Lei ^{[6
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China

[2] Southern Med Univ, Affiliated Hosp 3, Ctr Orthoped Surg, Dept Pediat Orthoped, Guangzhou 510515, Peoples R China

[3] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Orthoped Surg, Hangzhou 310003, Peoples R China

[5] Southern Med Univ, Nanfang Hosp, Dept Orthoped Surg, Guangzhou 510515, Peoples R China

[6] Guangzhou Med Univ, Affiliated Hosp 3, Dept Spine Surg, Guangzhou Key Lab Spine Dis Prevent & Treatment, Guangzhou 510150, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 13期

基金：

中国国家自然科学基金;

关键词：

antibacterials; dynamic cross-linking; injectable hydrogel adhesives; intrinsic photothermal properties; sealants;

D O I：

10.1002/adhm.202203306

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic photothermal hydrogel bioadhesive with an on-demand removal trait is developed through dynamic cross-linking of gelatin (Gel), tannic acid (TA) quinone, and borax for closing skin incisions and accelerating methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing. The TA quinone containing polyphenol and quinone groups with multifunctional adhesiveness and intrinsic photothermal performance confer the hydrogel adhesive with near-infrared (NIR) responsive antibacterial activity. The cross-linking of pH-sensitive boronic ester (polyphenol-B) and Schiff base bonds endow the hydrogel with great self-healing capacity and on-demand removability. Moreover, the hydrogel possesses good biocompatibility, injectability, and hemostasis. The in vivo experiment in a rat cutaneous incision model and full-thickness MRSA-infected wound model indicate that the smart hydrogel can close wounds efficiently and treat infected ones, demonstrating its superiority in noninvasive treatment of cutaneous incisions and enhancing infected full-thickness wound healing.

引用

页数：16