Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp.

被引：5

作者：

Sala, Samuele ^{[1
,2
,3
]}

Moggach, Stephen A. ^{[1
]}

Nealon, Gareth L. ^{[1
,4
]}

Fromont, Jane ^{[5
]}

Gomez, Oliver ^{[5
]}

Vuong, Daniel ^{[6
]}

Lacey, Ernest ^{[6
]}

Flematti, Gavin R. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Mol Sci, Crawley, WA 6009, Australia

[2] Murdoch Univ, Australian Natl Phenome Ctr, Harry Perkins Bldg, Perth, WA 6150, Australia

[3] Murdoch Univ, Hlth Futures Inst, Ctr Computat & Syst Med, Harry Perkins Bldg, Perth, WA 6150, Australia

[4] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia

[5] Western Australian Museum, Collect & Res, Welshpool, WA 6106, Australia

[6] Microbial Screening Technol Pty Ltd, Smithfield, NSW 2164, Australia

来源：

MARINE DRUGS | 2023年 / 21卷 / 01期

基金：

澳大利亚研究理事会; 中国国家自然科学基金;

关键词：

porphyrin; Isabela; hemin; X-ray diffraction; NOESY NMR; cytotoxic; DEMOSPONGE CORALLISTES-SP; CORAL SEA; BIOSYNTHESIS;

D O I：

10.3390/md21010041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two novel free porphyrins, isabellins A and B, as well as the known compounds corallistin D and deuteroporphyrin IX were isolated from a marine sponge Isabela sp. LC-MS analysis of the crude extract revealed that the natural products were present both as free porphyrins and iron(III) coordinated hemins, designated isabellihemin A, isabellihemin B, corallistihemin D and deuterohemin IX, respectively. Structures were determined via high-resolution mass spectrometry, UV-Vis spectroscopy and extensive NOESY NMR spectroscopic experiments. The type-I alkyl substitution pattern of isabellin A and isabellihemin A was assigned unambiguously by single crystal X-ray diffraction. Biological evaluation of the metabolites revealed potent cytotoxicity for isabellin A against the NS-1 murine myeloma cell line.

引用

页数：11

共 4 条

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