Effect of blood product transfusion on the prognosis of patients undergoing hepatectomy for hepatocellular carcinoma: a propensity score matching analysis

被引:15
作者
Nakayama, Hisashi [1 ]
Okamura, Yukiyasu [1 ]
Higaki, Tokio [1 ]
Moriguchi, Masamichi [1 ]
Takayama, Tadatoshi [1 ]
机构
[1] Nihon Univ, Sch Med, Dept Surg, Div Digest Surg, 30-1 Oyaguchikami Cho, Tokyo, Tokyo 1738610, Japan
关键词
Hepatectomy; Hepatocellular carcinoma; Blood transfusion; CURATIVE RESECTION; PORTAL-HYPERTENSION; SURVIVAL ANALYSIS; LIVER RESECTION; NO IMPACT; RECURRENCE; SURGERY; COHORT; CLASSIFICATION; CIRRHOSIS;
D O I
10.1007/s00535-022-01946-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Hepatectomy, the most common treatment for hepatocellular carcinoma, is associated with greater intraoperative blood loss than is resection of other malignancies. The effect of blood product transfusion (red blood cell [RBC], platelet, fresh frozen plasma [FFP], 5 and 25% albumin) on prognosis remains unclear. This study examined effects of blood product transfusion on prognoses of patients who underwent hepatectomy for hepatocellular carcinoma.Methods We included 2015 patients with pathologically confirmed hepatocellular carcinoma who underwent hepatectomy at our institution during 1990-2019. Patients (n = 534) who underwent repeat hepatectomy, non-curative hepatectomy, those with synchronous cancer in other organs, those who died within 1 month of surgery, and those with missing data were excluded. Finally, 1481 patients (1142 males, 339 females; median age: 68 years) with curability A or B were included.Results Intraoperative blood loss (> 500 mL) was an independent predictor of RBC transfusion (odds ratio, 8.482; P < 0.001). All transfusion groups had poorer recurrence-free survival (RFS) and overall survival (OS) than non-transfusion groups. After propensity score matching, the 5 year RFS rate was 13.4 and 16.3% in the RBC and no-RBC groups, respectively (P = 0.020). The RBC group had a significantly lower 5 year OS rate than the no-RBC group (42.1 vs. 48.8%, respectively; P = 0.035) and the FFP group (57.0%) than the no-FFP group (63.9%) (p = 0.047). No significant between-subgroup differences were found for other blood transfusion types.Conclusions RBC transfusion promotes hepatocellular carcinoma recurrence and RBC/FFP transfusions reduced long-term survival and RFS and OS in patients who underwent radical liver resection of HCC.
引用
收藏
页码:171 / 181
页数:11
相关论文
共 44 条
[21]  
Makino Y, 2000, AM J GASTROENTEROL, V95, P1294
[22]   SURGERY FOR SMALL LIVER CANCERS [J].
MAKUUCHI, M ;
KOSUGE, T ;
TAKAYAMA, T ;
YAMAZAKI, S ;
KAKAZU, T ;
MIYAGAWA, S ;
KAWASAKI, S .
SEMINARS IN SURGICAL ONCOLOGY, 1993, 9 (04) :298-304
[23]   Mortality After Common Rectal Surgery in Japan: A Study on Low Anterior Resection From a Newly Established Nationwide Large-Scale Clinical Database [J].
Matsubara, Nagahide ;
Miyata, Hiroaki ;
Gotoh, Mitsukazu ;
Tomita, Naohiro ;
Baba, Hideo ;
Kimura, Wataru ;
Nakagoe, Tohru ;
Simada, Mitsuo ;
Kitagawa, Yuko ;
Sugihara, Kenichi ;
Mori, Masaki .
DISEASES OF THE COLON & RECTUM, 2014, 57 (09) :1075-1081
[24]  
MATSUMATA T, 1993, CANCER, V72, P1866, DOI 10.1002/1097-0142(19930915)72:6<1866::AID-CNCR2820720613>3.0.CO
[25]  
2-F
[26]   Validation of the board certification system for expert surgeons (hepato-biliary-pancreatic field) using the data of the National Clinical Database of Japan: part 1-Hepatectomy of more than one segment [J].
Miura, Fumihiko ;
Yamamoto, Masakazu ;
Gotoh, Mitsukazu ;
Konno, Hiroyuki ;
Fujimoto, Jiro ;
Yanaga, Katsuhiko ;
Kokudo, Norihiro ;
Yamaue, Hiroki ;
Wakabayashi, Go ;
Seto, Yasuyuki ;
Unno, Michiaki ;
Miyata, Hiroaki ;
Hirahara, Norimichi ;
Miyazaki, Masaru .
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 2016, 23 (06) :313-323
[27]   Proposal of objective morphological classification system for hepatocellular carcinoma using preoperative multiphase computed tomography [J].
Nakayama, Hisashi ;
Takayama, Tadatoshi ;
Okubo, Takao ;
Higaki, Tokio ;
Midorikawa, Yutaka ;
Moriguchi, Masamichi ;
Itoh, Akiyoshi .
JOURNAL OF GASTROENTEROLOGY, 2014, 49 (10) :1430-1437
[28]   IMPROVEMENT OF KIDNEY-GRAFT SURVIVAL WITH INCREASED NUMBERS OF BLOOD TRANSFUSIONS [J].
OPELZ, G ;
TERASAKI, PI .
NEW ENGLAND JOURNAL OF MEDICINE, 1978, 299 (15) :799-803
[29]   No impact of perioperative blood transfusion on prognosis after curative resection for hepatocellular carcinoma: a propensity score matching analysis [J].
Peng, T. ;
Zhao, G. ;
Wang, L. ;
Wu, J. ;
Cui, H. ;
Liang, Y. ;
Zhou, R. ;
Liu, Z. ;
Wang, Q. .
CLINICAL & TRANSLATIONAL ONCOLOGY, 2018, 20 (06) :719-728
[30]   Impact of perioperative allogeneic blood transfusion on the long-term prognosis of patients with different stage tumors after radical resection for hepatocellular carcinoma [J].
Peng, Tao ;
Wang, Liming ;
Cui, Hongyuan ;
Li, Xiying ;
Liu, Min ;
Yu, Jingjing ;
Wu, Jianxiong ;
Zhao, Guohua ;
Liu, Zhong .
EJSO, 2021, 47 (03) :620-627