Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer's disease and strategies for treatment

被引：16
作者：
Chaves, Juliana C. S. [1 ,2 ]
Dando, Samantha J. [3 ]
White, Anthony R. [1 ,2 ]
Oikari, Lotta E. [1 ,2 ]
机构：
[1] QIMR Berghofer Med Res Inst, Mental Hlth & Neurosci Program, Brisbane, Qld, Australia
[2] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Qld, Australia
[3] Queensland Univ Technol, Fac Hlth, Ctr Immunol & Infect Control, Sch Biomed Sci, Brisbane, Australia
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 02期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Blood-brain-barrier (BBB); BBB transporters; BBB disruption; Alzheimer's diseases; BBB modulation; Drug delivery; ATP-BINDING CASSETTE; AMYLOID-BETA-PEPTIDE; CANCER RESISTANCE PROTEIN; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID TRANSPORTER; POLYPEPTIDE; 1A2; OATP1A2; IN-VIVO EVIDENCE; P-GLYCOPROTEIN; ABC TRANSPORTERS; A-BETA;
D O I：
10.1016/j.bbadis.2023.166967
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by regulating the entry of molecules from the blood to the brain. Key players in BBB function are BBB transporters which are highly expressed in brain endothelial cells (BECs) and critical in mediating the exchange of nutrients and waste products. BBB transporters can also influence drug delivery into the brain by inhibiting or facilitating the entry of brain targeting therapeutics for the treatment of brain disorders, such as Alzheimer's disease (AD). Recent studies have shown that AD is associated with a disrupted BBB and transporter dysfunction, although their roles in the development in AD are not fully understand. Modulation of BBB transporter activity may pose a novel approach to enhance the delivery of drugs to the brain for enhanced treatment of AD. In this review, we will give an overview of key functions of BBB transporters and known changes in AD. In addition, we will discuss current strategies for transporter modulation for enhanced drug delivery into the brain.
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页数：18
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